公开(公告)号：US20190142805A1

公开(公告)日：2019-05-16

申请号：US16246833

申请日：2019-01-14

申请人： Ardea Biosciences, Inc.

发明人： Barry D. Quart ,  Jean-Luc Giradet ,  Esmir Gunic ,  Li-Tain Yeh

IPC分类号： A61K31/4196 ,  C07H7/02 ,  A61K31/7056 ,  C07H19/16 ,  A61K31/7068 ,  C07D249/12 ,  A61K31/7076 ,  A61K45/06 ,  C07D249/14 ,  C07H19/06 ,  A61K31/7072

摘要： Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

公开(公告)号：US10047050B2

公开(公告)日：2018-08-14

申请号：US14355480

申请日：2012-11-02

申请人： ARDEA BIOSCIENCES, INC.

发明人： Li-Tain Yeh ,  Barry D. Quart

IPC分类号： C07D213/70 ,  A61K31/44 ,  A61K45/06 ,  A61K31/426 ,  A61K31/519 ,  A61K31/4418

CPC分类号： C07D213/70 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

摘要： 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is useful in the modulation of blood or serum uric acid levels. In some embodiments, 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used in the treatment or prevention of disorders related to aberrant levels of uric acid. In some embodiments, 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used for reducing serum uric acid levels in a human. Also described herein are compositions comprising 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid, and their use in the modulation of blood or serum uric acid levels.

公开(公告)号：US10570095B2

公开(公告)日：2020-02-25

申请号：US16030410

申请日：2018-07-09

申请人： Ardea Biosciences, Inc.

发明人： Li-Tain Yeh ,  Barry D. Quart

IPC分类号： C07D213/70 ,  A61K31/44 ,  A61K45/06 ,  A61K31/426 ,  A61K31/519 ,  A61K31/4418

摘要： 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is useful in the modulation of blood or serum uric acid levels. In some embodiments, 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used in the treatment or prevention of disorders related to aberrant levels of uric acid. In some embodiments, 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used for reducing serum uric acid levels in a human. Also described herein are compositions comprising 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid, and their use in the modulation of blood or serum uric acid levels.

公开(公告)号：US10183012B2

公开(公告)日：2019-01-22

申请号：US15358586

申请日：2016-11-22

申请人： Ardea Biosciences, Inc.

发明人： Barry D. Quart ,  Jean-Luc Girardet ,  Esmir Gunic ,  Li-Tain Yeh

IPC分类号： A61K31/4196 ,  C07D249/12 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K45/06 ,  C07D249/14 ,  C07H19/06 ,  C07H19/16 ,  A61K31/7056 ,  C07H7/02

摘要： Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

公开(公告)号：US20140256748A1

公开(公告)日：2014-09-11

申请号：US14355480

申请日：2012-10-02

申请人： ARDEA BIOSCIENCES, INC.

发明人： Li-Tain Yeh ,  Barry D. Quart

IPC分类号： C07D213/70 ,  A61K45/06 ,  A61K31/4418

CPC分类号： C07D213/70 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

摘要： 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is useful in the modulation of blood or serum uric acid levels. In some embodiments, 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used in the treatment or prevention of disorders related to aberrant levels of uric acid. In some embodiments, 2-((3-(4-cyanonaph-thalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid is used for reducing serum uric acid levels in a human. Also described herein are compositions comprising 2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoic acid, and their use in the modulation of blood or serum uric acid levels.

摘要翻译： 2 - （（3-（4-氰基萘-1-基）吡啶-4-基）硫基）-2-甲基丙酸可用于调节血液或血清尿酸水平。 在一些实施方案中，使用2 - （（3-（4-氰基萘-1-基）吡啶-4-基）硫代）-2-甲基丙酸来治疗或预防与尿酸异常水平相关的疾病。 在一些实施方案中，使用2 - （（3-（4-氰基萘-2-基）吡啶-4-基）硫基）-2-甲基丙酸来降低人体血清尿酸水平。 本文还描述了包含2 - （（3-（4-氰基萘-1-基）吡啶-4-基）硫代）-2-甲基丙酸的组合物及其在调节血液或血清尿酸水平中的用途。