公开(公告)号：US11254941B2

公开(公告)日：2022-02-22

申请号：US16642792

申请日：2018-08-30

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao Yan ,  Yung Chang ,  Xiaowei Liu ,  Fei Zhang ,  Xiaodong Qi

IPC: C12N15/117 ,  B82Y5/00

Abstract: Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

公开(公告)号：US11242533B2

公开(公告)日：2022-02-08

申请号：US16954458

申请日：2019-01-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Yung Chang ,  Hao Yan ,  Xiaodong Qi ,  Fei Zhang

IPC: C12N15/117 ,  B82Y5/00 ,  A61K38/00 ,  A61K39/00

Abstract: Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.