公开(公告)号：US20210164991A1

公开(公告)日：2021-06-03

申请号：US16954187

申请日：2019-01-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Stephen JOHNSTON ,  Lu WANG

IPC: G01N33/68 ,  C12N7/00 ,  C12N1/10 ,  C12N1/20 ,  C07K14/47

Abstract: A method of inducing a generalized immune response, includes administering to a subject an immunologically effective amount of one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46, thereby inducing a generalized immune response to infection by a pathogen in a subject. A prophylactic or therapeutic composition for inducing a generalized immune response, includes an immunologically effective amount of one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46. A method of distinguishing a subject infected with a pathogen from an uninfected subject, includes detecting an antibody in the subject that selectively binds one or more isolated immunogenic peptides comprising an amino acid sequence of SEQ. ID NOs: 1-46, wherein the presence of the antibody indicates that the subject is infected with the pathogen. A general method to discover broadly protective components for a vaccine is also disclosed.