公开(公告)号：US20240019429A1

公开(公告)日：2024-01-18

申请号：US18349650

申请日：2023-07-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Shaopeng WANG ,  Guangzhong MA ,  Xiaoyan ZHOU

IPC: G01N33/557 ,  G01N33/543 ,  G01N21/552

CPC classification number: G01N33/557 ,  G01N33/54373 ,  G01N21/553

Abstract: Provided herein are methods of determining binding kinetics of a ligand. In some embodiments, the methods include contacting the ligand with a first surface of a substrate, which first surface comprises an electrically conductive coating and a population of receptors connected to the first surface via one or more linker moieties, wherein the receptors bind, or are capable of binding, to the ligand, applying an alternating current electric field to the substrate to induce the receptors to oscillate proximal to the first surface of the substrate, and detecting changes in oscillation amplitudes of the receptors over a duration. Related receptor oscillator array devices, systems and computer readable media are also provided.