公开(公告)号：US20180224448A1

公开(公告)日：2018-08-09

申请号：US15892981

申请日：2018-02-09

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： Haoyu Wang ,  Ji Qiu ,  Joshua LaBaer ,  Jonathan Leighton ,  Shabana Pasha

IPC分类号： G01N33/564 ,  G01N33/50 ,  G01N33/52 ,  G01N33/543 ,  C12N15/10 ,  C07K16/18

CPC分类号： G01N33/564 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/30 ,  C12N15/1065 ,  C12N2310/3519 ,  G01N33/5023 ,  G01N33/521 ,  G01N33/54353 ,  G01N33/5436 ,  G01N33/54393 ,  G01N2800/065

摘要： Identification of autoantibodies associated with Crohn's disease useful in diagnosis and management using an innovative protein array technology, namely nucleic acid programmable protein arrays (NAPPA) and applications relating thereto. Overall, reactivity of IgG autoantibodies was stronger than that of IgA autoantibodies; however, IgA autoantibodies showed greater differential reactivity between cases and controls. Four IgA autoantibodies against SNRPB, PRPH, PTTG1 and SNAI1 were newly identified with sensitivities above 15% at 95% specificity, among which anti-SNRPB-IgA had the highest sensitivity of 24.0%. Autoantibodies associated with specific disease subtypes were also found.

公开(公告)号：US10648978B2

公开(公告)日：2020-05-12

申请号：US15892981

申请日：2018-02-09

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： Haoyu Wang ,  Ji Qiu ,  Joshua LaBaer ,  Jonathan Leighton ,  Shabana Pasha

IPC分类号： G01N33/564 ,  G01N33/50 ,  G01N33/52 ,  G01N33/543 ,  C12N15/10 ,  C07K16/18 ,  C07K16/30 ,  C07K16/40

摘要： Identification of autoantibodies associated with Crohn's disease useful in diagnosis and management using an innovative protein array technology, namely nucleic acid programmable protein arrays (NAPPA) and applications relating thereto. Overall, reactivity of IgG autoantibodies was stronger than that of IgA autoantibodies; however, IgA autoantibodies showed greater differential reactivity between cases and controls. Four IgA autoantibodies against SNRPB, PRPH, PTTG1 and SNAI1 were newly identified with sensitivities above 15% at 95% specificity, among which anti-SNRPB-IgA had the highest sensitivity of 24.0%. Autoantibodies associated with specific disease subtypes were also found.