公开(公告)号：US20240360107A1

公开(公告)日：2024-10-31

申请号：US18687664

申请日：2022-08-30

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Eli Chapman ,  Christopher Zerio

IPC分类号： C07D405/04 ,  A61K31/4709

CPC分类号： C07D405/04 ,  A61K31/4709

摘要： The present invention features inhibitors of the eIF4A enzyme. These inhibitors have a novel mechanism for inhibiting the eIF4A enzyme by occupying a binding pocket within the eIF4A RNA-binding groove, thereby perturbing RNA binding, blocking ATP hydrolysis, and, consequently, inhibiting RNA helicase activity. Thus, the compounds of the present invention are RNA-competitive, ATP-uncompetitive elF4A inhibitors that directly bind elF4A and inhibit the protein.