公开(公告)号：US20200308194A1

公开(公告)日：2020-10-01

申请号：US16902424

申请日：2020-06-16

Applicant: Loxo Oncology, Inc. ,  Array BioPharma Inc.

Inventor： Charles Todd EARY ,  Stacey SPENCER ,  Zack CRANE ,  Katelyn CHANDO ,  Sylvie ASSELIN ,  Weidong LIU ,  Mike WELCH ,  Adam COOK ,  Gabrielle R. KOLAKOWSKI ,  Andrew T. METCALF ,  David A. MORENO ,  Tony P. TANG

IPC: C07D519/00 ,  C07D471/04

Abstract: In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.

公开(公告)号：US20210380609A1

公开(公告)日：2021-12-09

申请号：US17401892

申请日：2021-08-13

Applicant: Loxo Oncology, Inc. ,  Array BioPharma Inc.

Inventor： Charles Todd EARY ,  Stacey SPENCER ,  Zack CRANE ,  Katelyn CHANDO ,  Sylvie ASSELIN ,  Weidong LIU ,  Mike WELCH ,  Adam COOK ,  Gabrielle R. KOLAKOWSKI ,  Andrew T. METCALF ,  David A. MORENO ,  Tony P. TANG

IPC: C07D519/00 ,  C07D471/04

Abstract: In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.

公开(公告)号：US20160200723A1

公开(公告)日：2016-07-14

申请号：US14913635

申请日：2014-08-21

Applicant: GENENTECH, INC. ,  ARRAY BIOPHARMA INC.

Inventor： Chong HAN ,  Keena GREEN ,  Francis GOSSELIN ,  Michelangelo SCALONE ,  Paul J. NICHOLS ,  Weidong LIU ,  Keith L. SPENCER ,  Zackary D. CRANE ,  Peter J. STENGEL ,  Sagar SHAKYA

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.

Abstract translation: 本发明提供了可用于制备可用作CHK1抑制剂的化合物的制备方法。

公开(公告)号：US20140023643A1

公开(公告)日：2014-01-23

申请号：US14034361

申请日：2013-09-23

Applicant: ARRAY BIOPHARMA, INC.

Inventor： Joseph P. LYSSIKATOS ,  Julie Marie GRESCHUK ,  Fredrik P. MARMSATER ,  Qian ZHAO ,  D. David HENNINGS ,  Weidong LIU

IPC: C07D471/04 ,  A61K39/395 ,  A61K31/337 ,  A61K31/517 ,  A61K31/513

CPC classification number: A61K31/337 ,  A61K31/513 ,  A61K31/517 ,  A61K39/3955 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D519/00

Abstract: This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

Abstract translation: 本发明提供式I化合物，其中B，G，A，E，R 1，R 2，R 3，m和n如本文所定义，其可用作I型受体酪氨酸激酶抑制剂，及其用于治疗 哺乳动物过度增生性疾病。