专利检索 ap:("ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE" OR "INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)" OR "UNIVERSITE D'AIX-MARSEILLE" OR "QUEEN MARY UNIVERSITY OF LONDON" OR "SORBONNE UNIVERSITÉ") AND inv:"ALEXANDRINE BERTAUD" 第 1 页

1.

发明申请
CD146 AND USES THEREOF AS A BIOMARKER AND AS A THERAPEUTIC TARGET IN THE DIAGNOSIS AND TREATMENT OF FIBROSIS 有权

公开(公告)号：US20220003784A1

公开(公告)日：2022-01-06

申请号：US17280202

申请日：2019-09-26

申请人： ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE D'AIX-MARSEILLE , QUEEN MARY UNIVERSITY OF LONDON , SORBONNE UNIVERSITÉ

发明人： AURÉLIE LEROYER , MARCEL BLOT-CHABAUD , CHRISTOS CHADJICHRISTOS , NATHALIE BARDIN , FRANÇOISE DIGNAT-GEORGE , ALEXANDRINE BERTAUD , BENJAMIN GUILLET , CHRISTOPH THIEMERMANN , GUILLAUME HACHE

IPC分类号： G01N33/68 , C07K16/30 , A61K38/17 , A61P19/04

摘要： The present invention relates to the field of medicine and in particular to the diagnostic and treatment of fibrosis. More particularly, the invention relates to CD146 and uses thereof as a biomarker in the diagnosis of fibrosis and as a therapeutic target in the treatment of fibrosis. The invention also relates to compositions and methods of detecting predisposition to, of diagnosing, prognosing and/or monitoring fibrosis in a subject. It further relates to CD146 inhibitors, and to compositions comprising a CD146 inhibitor, for use in prevention or treatment of fibrosis in a subject, as well as to compositions, kits and uses thereof in a diagnostic or therapeutic context.