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公开(公告)号：US12077526B2
公开(公告)日：2024-09-03
申请号：US18159452
申请日：2023-01-25
发明人： Steven Howard , Benjamin David Cons , Jeffrey David St. Denis , Rhian Sara Holvey , Guillaume François Parra , Kim Louise Hirst , Isabelle Anne Lemasson , David John Nash , James Daniel Osborne , Jonas Calleja Priede , Nicholas Paul Richards , Aaron Michael Dumas , Brian Christopher Bishop , David Parry-Jones , Meenakshi Sundaram Shanmugham , Darren James Dixon , Matthew James Gaunt
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/13
摘要： The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US10526311B2
公开(公告)日：2020-01-07
申请号：US15763724
申请日：2016-09-29
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D401/06 , A61K31/4439 , C07D401/14 , C07D403/06 , C07D407/14 , C07D409/14 , C07D417/14 , A61P35/00 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US11261171B1
公开(公告)日：2022-03-01
申请号：US16680969
申请日：2019-11-12
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D401/06 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4545 , A61K31/444 , A61K31/4439 , A61P35/00 , C07D417/14 , C07D409/14 , C07D407/14 , C07D403/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D487/04 , C07B59/00 , C07D487/08 , A61K45/06
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US10544132B2
公开(公告)日：2020-01-28
申请号：US15763698
申请日：2016-09-29
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US12071429B2
公开(公告)日：2024-08-27
申请号：US17164045
申请日：2021-02-01
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
CPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/5728 , C07B2200/05
摘要： The invention provides a compound of formula (I):
or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US11603367B2
公开(公告)日：2023-03-14
申请号：US16498207
申请日：2018-03-28
发明人： Steven Howard , Jeffrey David St. Denis , Charlotte Mary Griffiths-Jones , Steven Douglas Hiscock , Alan Richard Burns , David Cousin , Kim Louise Hirst , James Daniel Osborne , Jonas Calleja Priede , Aaron Michael Dumas , Brian Christopher Bishop , David Parry-Jones , Jeremy Peter Scott , Meenakshi Sundaram Shanmugham , Peter Richard Mullens , Darren James Dixon , Matthew James Gaunt
IPC分类号： C07D405/06
摘要： The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US10981898B2
公开(公告)日：2021-04-20
申请号：US16535931
申请日：2019-08-08
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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