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公开(公告)号：US11261171B1
公开(公告)日：2022-03-01
申请号：US16680969
申请日：2019-11-12
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D401/06 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4545 , A61K31/444 , A61K31/4439 , A61P35/00 , C07D417/14 , C07D409/14 , C07D407/14 , C07D403/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D487/04 , C07B59/00 , C07D487/08 , A61K45/06
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US12071429B2
公开(公告)日：2024-08-27
申请号：US17164045
申请日：2021-02-01
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
CPC分类号： C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/5728 , C07B2200/05
摘要： The invention provides a compound of formula (I):
or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US10981898B2
公开(公告)日：2021-04-20
申请号：US16535931
申请日：2019-08-08
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US10526311B2
公开(公告)日：2020-01-07
申请号：US15763724
申请日：2016-09-29
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D401/06 , A61K31/4439 , C07D401/14 , C07D403/06 , C07D407/14 , C07D409/14 , C07D417/14 , A61P35/00 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US10544132B2
公开(公告)日：2020-01-28
申请号：US15763698
申请日：2016-09-29
发明人： Gianni Chessari , Steven Howard , Ildiko Maria Buck , Benjamin David Cons , Christopher Norbert Johnson , Rhian Sara Holvey , David Charles Rees , Jeffrey David St. Denis , Emiliano Tamanini , Bernard Thomas Golding , Ian Robert Hardcastle , Celine Florence Cano , Duncan Charles Miller , Martin Edward Mäntylä Noble , Roger John Griffin , James Daniel Osborne , Joanne Peach , Arwel Lewis , Kim Louise Hirst , Benjamin Paul Whittaker , David Wyn Watson , Dale Robert Mitchell
IPC分类号： C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00
摘要： The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20140194486A1
公开(公告)日：2014-07-10
申请号：US14085632
申请日：2013-11-20
发明人： Bernard Thomas GOLDING , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC分类号： A61K31/4035 , C07D209/48
CPC分类号： C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
摘要： A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
摘要翻译： 式（I）化合物或式（II）化合物或其药学上可接受的盐，其中R 1 -R 7和X如说明书中所定义，以及这些化合物在治疗中的用途，特别是在治疗癌症或作为 MDM2蛋白与p53相互作用的抑制剂。
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公开(公告)号：US09358222B2
公开(公告)日：2016-06-07
申请号：US14085632
申请日：2013-11-20
发明人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC分类号： C07D207/46 , A61K31/4035 , C07D209/48 , C07D401/06 , C07D403/06
CPC分类号： C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
摘要： A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
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公开(公告)号：US10414726B2
公开(公告)日：2019-09-17
申请号：US15715900
申请日：2017-09-26
发明人： Bernard Thomas Golding , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC分类号： C07D209/49 , C07D209/48 , C07D401/06 , C07D403/06 , A61K31/4035 , A61K31/4402 , A61K45/06
摘要： A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
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