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![5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents](/abs-image/US/2018/09/18/USRE47047E1/abs.jpg.150x150.jpg)
公开(公告)号：USRE47047E1
公开(公告)日：2018-09-18
申请号：US15080187
申请日：2016-03-24
发明人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schaecke
IPC分类号： A61K31/04 , C07D215/38 , C07C45/00 , C07D405/12 , C07C45/58 , C07C49/84 , C07C45/71 , C07C49/82 , C07D303/32
摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
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公开(公告)号：US20150005309A1
公开(公告)日：2015-01-01
申请号：US14370831
申请日：2013-01-08
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US09604989B2
公开(公告)日：2017-03-28
申请号：US14792205
申请日：2015-07-06
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention relates to a method for the treatment of a cancer that is sensitive to Pi3K/Akt pathway inhibition by administering a therapeutically effective amount of a compound of formula (I)
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公开(公告)号：US09260435B2
公开(公告)日：2016-02-16
申请号：US14370831
申请日：2013-01-08
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号： C07D487/04 , A61K45/06 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US09370517B2
公开(公告)日：2016-06-21
申请号：US14371567
申请日：2013-01-08
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号： A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US09738632B2
公开(公告)日：2017-08-22
申请号：US15367936
申请日：2016-12-02
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepisto , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D409/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , A61K31/4439 , A61K45/06 , C07D405/10 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
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公开(公告)号：US09512110B2
公开(公告)日：2016-12-06
申请号：US14547809
申请日：2014-11-19
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D231/54 , C07D409/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , A61K31/4439 , A61K45/06
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：US20170081315A1
公开(公告)日：2017-03-23
申请号：US15367936
申请日：2016-12-02
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepisto , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： C07D409/14 , A61K31/416 , C07D405/10 , A61K31/4439 , A61K45/06 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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公开(公告)号：US20150080434A1
公开(公告)日：2015-03-19
申请号：US14547809
申请日：2014-11-19
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Thomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： C07D409/14 , A61K45/06 , C07D405/12 , A61K31/4439 , A61K31/416 , C07D405/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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