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公开(公告)号：US09512110B2
公开(公告)日：2016-12-06
申请号：US14547809
申请日：2014-11-19
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D231/54 , C07D409/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , A61K31/4439 , A61K45/06
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：US09738632B2
公开(公告)日：2017-08-22
申请号：US15367936
申请日：2016-12-02
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepisto , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D409/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , A61K31/4439 , A61K45/06 , C07D405/10 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
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公开(公告)号：US20170081315A1
公开(公告)日：2017-03-23
申请号：US15367936
申请日：2016-12-02
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepisto , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： C07D409/14 , A61K31/416 , C07D405/10 , A61K31/4439 , A61K45/06 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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公开(公告)号：US20150080434A1
公开(公告)日：2015-03-19
申请号：US14547809
申请日：2014-11-19
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmen , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Thomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： C07D409/14 , A61K45/06 , C07D405/12 , A61K31/4439 , A61K31/416 , C07D405/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：US09951027B2
公开(公告)日：2018-04-24
申请号：US15118157
申请日：2015-02-10
发明人： Hartmut Rehwinkel , Holger Siebeneicher , Sonja Anlauf , Duy Nguyen , Olaf Panknin , Sven Ring , Wolfgang Schwede , Marcus Bauser , Katja Zimmermann , Stefan Kaulfuss , Roland Neuhaus
IPC分类号： C07D235/30 , C07D409/12 , C07D401/12 , C07D405/12
CPC分类号： C07D235/30 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10138226B2
公开(公告)日：2018-11-27
申请号：US15520385
申请日：2015-10-20
IPC分类号： C07D235/30 , C07D409/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09957235B2
公开(公告)日：2018-05-01
申请号：US15118154
申请日：2015-02-10
发明人： Hartmut Rehwinkel , Olaf Panknin , Sven Ring , Sonja Anlauf , Holger Siebeneicher , Duy Nguyen , Wolfgang Schwede , Marcus Bauser , Katja Zimmermann , Stefan Kaulfuss , Roland Neuhaus , Paul Matthew Blaney
IPC分类号： C07D235/30 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/12
CPC分类号： C07D235/30 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09260435B2
公开(公告)日：2016-02-16
申请号：US14370831
申请日：2013-01-08
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号： C07D487/04 , A61K45/06 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US20150005309A1
公开(公告)日：2015-01-01
申请号：US14370831
申请日：2013-01-08
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Pi3K / Akt途径的有效抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US10919862B2
公开(公告)日：2021-02-16
申请号：US15746352
申请日：2016-07-14
发明人： Olaf Panknin , Ingo Hartung , Hartmut Rehwinkel , Duy Nguyen , Ludwig Zorn , Petra Helfrich , Katja Zimmermann , Roland Neuhaus
IPC分类号： C07D235/30 , C07D471/04 , A61P35/00 , A61K31/4184 , A61K31/437 , A61K45/06 , C12P17/10
摘要： The present invention relates to compounds of general formula (I): in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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