公开(公告)号：US20250027902A1

公开(公告)日：2025-01-23

申请号：US18909305

申请日：2024-10-08

Applicant: AUBURN UNIVERSITY ,  MERCER UNIVERSITY

Inventor： Masoud MAHJOURI-SAMANI ,  Michael C. HAMILTON ,  Marcelo A. KURODA ,  Sahar HASIM ,  Parvin FATHI-HAFSHEJANI

IPC: G01N27/414

Abstract: In at least one illustrative embodiment, a field-effect transistor biosensor for detection of a pathogen includes a substrate and a channel formed from a two-dimensional monolayer or few-layer metal chalcogenide that is functionalized with a biorecognition element. The biorecognition element may be an antibody, such as an antibody for the SARS-COV-2 spike protein. A method for manufacturing the biosensor includes depositing an amorphous two-dimensional material on the substrate with pulsed laser ablation, crystallizing the amorphous two-dimensional material to generate a two-dimensional monolayer coupled to the substrate, and activating a surface of the two-dimensional material with the biorecognition element after crystallizing the amorphous two-dimensional material. The composition of the two-dimensional material may be tuned. The substrate may be photolithographically patterned. Other embodiments are described and claimed.