公开(公告)号：US20230148144A1

公开(公告)日：2023-05-11

申请号：US17915802

申请日：2021-04-08

申请人： AUTOLUS LIMITED

发明人： Shaun Cordoba ,  Martin Pulé ,  Vania Baldan ,  Alex Nicholson

IPC分类号： A61K35/17 ,  C12N9/16 ,  C07K14/74 ,  C07K14/725 ,  C12N5/0783 ,  A61K31/436 ,  A61K38/17

CPC分类号： A61K35/17 ,  C12N9/16 ,  C12Y301/03016 ,  C07K14/70539 ,  C07K14/7051 ,  C12N5/0636 ,  A61K31/436 ,  A61K38/1774 ,  C07K2319/30 ,  C07K2319/03 ,  A61K2035/122

摘要： There is provided an effector immune cell which expresses a cell surface receptor or receptor complex which specifically binds an antigen recognition receptor of a target immune cell; which effector immune cell is engineered such that when a synapse is formed between the effector immune cell and the target immune cell, the capacity of the effector immune cell to kill the target immune cell is greater than the capacity of the target immune cell to kill the effector immune cell. There is also provided the use of such a cell in methods for treating cancer, preventing allograft rejection and GVHD.