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公开(公告)号：US11912779B2
公开(公告)日：2024-02-27
申请号：US17932653
申请日：2022-09-15
IPC分类号： C07K16/28 , A61P21/00 , C12N15/113 , A61K39/00
CPC分类号： C07K16/2881 , A61P21/00 , C12N15/113 , A61K2039/505 , C12N2310/141 , C12N2310/315 , C12N2310/321
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating facioscapulohumeral muscular dystrophy (FSHD).
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公开(公告)号：US11834510B2
公开(公告)日：2023-12-05
申请号：US17243362
申请日：2021-04-28
IPC分类号： A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00
CPC分类号： C07K16/2881 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565
摘要： Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.
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公开(公告)号：US11707532B2
公开(公告)日：2023-07-25
申请号：US17818319
申请日：2022-08-08
发明人： Venkata Ramana Doppalapudi , Michael David Hood , Rob Burke , Michael Caramian Cochran , Beatrice Diana Darimont , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： A61K47/68 , C12N15/113
CPC分类号： A61K47/6807 , A61K47/6849 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3513
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle dystrophy (DM1).
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公开(公告)号：US11576980B2
公开(公告)日：2023-02-14
申请号：US17529207
申请日：2021-11-17
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US11497814B2
公开(公告)日：2022-11-15
申请号：US17529197
申请日：2021-11-17
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US11028179B2
公开(公告)日：2021-06-08
申请号：US17133413
申请日：2020-12-23
摘要： Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.
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公开(公告)号：US11583591B2
公开(公告)日：2023-02-21
申请号：US17464618
申请日：2021-09-01
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US11555190B2
公开(公告)日：2023-01-17
申请号：US17200612
申请日：2021-03-12
IPC分类号： C12N15/113 , C07K19/00 , C07K16/28 , A61K47/68 , A61P21/00 , A61K48/00 , A61P21/06 , A61K31/7125
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.
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公开(公告)号：US11253607B2
公开(公告)日：2022-02-22
申请号：US17024624
申请日：2020-09-17
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Michael Hood , Beatrice Diana Darimont , Rob Burke , Yunyu Shi , Gulin Erdogan Marelius , Barbora Malecova
IPC分类号： C07H21/04 , A61K47/68 , A61K31/712 , A61K31/713 , C07K16/18 , C12N15/113 , A61P21/00 , A61K39/395 , A61K9/51
摘要： Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
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公开(公告)号：US10800848B2
公开(公告)日：2020-10-13
申请号：US16128417
申请日：2018-09-11
发明人： Andrew John Geall , Venkata Ramana Doppalapudi , David Sai-Ho Chu , Michael Caramian Cochran , Rachel Elizabeth Johns , Palani Balu , Rob Burke , Beatrice Diana Darimont
IPC分类号： C07K16/28 , C12N15/113 , A61K31/713 , A61K47/68 , C12N15/88 , A61K47/60 , A61P35/00 , C07K16/30 , A61P35/02 , A61K31/7088 , A61K48/00 , A61K39/00
摘要： Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
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