公开(公告)号：US20160324781A1

公开(公告)日：2016-11-10

申请号：US15219602

申请日：2016-07-26

申请人： AXOLABS GMBH

发明人： Rainer CONSTIEN ,  Anke GEICK ,  Philipp HADWIGER ,  Torsten HANEKE ,  Ludger ICKENSTEIN ,  Carla Alexandra HERNANDEZ PRATA ,  Andrea SCHUSTER ,  Timo WEIDE

IPC分类号： A61K9/14 ,  C07D241/04 ,  A61K31/713 ,  C07D295/13

CPC分类号： A61K9/145 ,  A61K9/1271 ,  A61K31/575 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  B82Y5/00 ,  C07C211/11 ,  C07C211/13 ,  C07C211/14 ,  C07C211/22 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42 ,  C07D241/04 ,  C07D295/13 ,  C07D295/30

摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.