公开(公告)号：US20240269289A1

公开(公告)日：2024-08-15

申请号：US18589688

申请日：2024-02-28

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin MAIER ,  Muthusamy JAYARAMAN ,  Akin AKINC ,  Shigeo MATSUDA ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN ,  Jayaprakash K. NAIR ,  Thomas A. BAILLIE

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/02

CPC分类号： A61K47/18 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/022

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20180303092A1

公开(公告)日：2018-10-25

申请号：US15957008

申请日：2018-04-19

申请人： Taminco BVBA

发明人： Karen Mollet ,  Michael Schmidt ,  Kristof Moonen ,  Peter Roose ,  Jim Van Durme

IPC分类号： A01N39/04 ,  C07C215/08 ,  C07C65/21 ,  C07C211/11 ,  C07C59/70 ,  C07C211/07 ,  C07C209/68 ,  C07C51/41 ,  C07C213/08 ,  A01N37/40 ,  A01N25/02

CPC分类号： A01N39/04 ,  A01N25/02 ,  A01N37/40 ,  C07C51/412 ,  C07C59/70 ,  C07C65/21 ,  C07C209/68 ,  C07C211/07 ,  C07C211/11 ,  C07C213/08 ,  C07C215/08

摘要： The invention generally involves combining specialty amines with herbicidal carboxylic acids to form a new generation of salts with improved characteristics. The salts contain a cation of an amine and an anion of a carboxylic acid herbicide. The amine is advantageously selected from mono-isobutylamine (MIBA), N-methylaminoethanol (MMEA), dimethylaminopropylamine (DMAPA), 2-dimethylaminoethanol (DMAE), methyldiethanolamine (MDEA), and 1,2-diaminopropane (1,2-DAP). The amine-herbicide combinations may possess one or more improved characteristics, including maximum loading, wettability, drift, viscosity, and volatilization.

公开(公告)号：US20180303091A1

公开(公告)日：2018-10-25

申请号：US15957013

申请日：2018-04-19

申请人： Taminco BVBA

发明人： Jim Van Durme ,  Michael Schmidt ,  Karen Mollet ,  Kristof Moonen ,  Peter Roose

IPC分类号： A01N37/40 ,  A01N25/02 ,  C07C213/08 ,  C07C215/08 ,  C07C217/08 ,  C07C215/10 ,  C07C65/21 ,  C07C51/41 ,  C07F9/38 ,  A01N57/20 ,  C07C59/70 ,  A01N39/04 ,  C07C209/68 ,  C07C211/11 ,  C07C255/30 ,  C07C253/30

CPC分类号： A01N37/40 ,  A01N25/02 ,  A01N39/04 ,  A01N57/20 ,  C07C51/412 ,  C07C59/70 ,  C07C65/21 ,  C07C209/68 ,  C07C211/11 ,  C07C213/08 ,  C07C215/08 ,  C07C215/10 ,  C07C217/08 ,  C07C253/30 ,  C07C255/30 ,  C07F9/3808 ,  C07F9/3813

摘要： The invention is a herbicidal composition containing an alkanolamine salt of an dicamba capable of remaining as a single phase liquid over a period of at least 1 week and containing low amounts of water and high loadings of the salt. Such herbicidal compositions are capable of remaining liquid in the absence of high amounts of water, thereby enhancing their capacity to remain liquid over an extended period of time when exposed to environmental conditions to improve their effectiveness to transport the active salt through a leafy substrate and can reduce transportation costs by increasing the salt loading without compromising the stability of the composition.

公开(公告)号：US09981904B2

公开(公告)日：2018-05-29

申请号：US15505803

申请日：2015-08-25

申请人： BASF SE

发明人： Christof Wilhelm Wigbers ,  Wolfgang Maegerlein ,  Thomas Krug ,  Johann-Peter Melder ,  Thomas Heidemann ,  Bernd Stein

IPC分类号： C07C209/48 ,  B01J23/75 ,  B01J37/18 ,  B01J35/00 ,  B01J23/78

CPC分类号： C07C209/48 ,  B01J23/75 ,  B01J23/78 ,  B01J35/0006 ,  B01J35/002 ,  B01J37/18 ,  C07C2523/75 ,  Y02P20/582 ,  C07C211/11 ,  C07C211/09 ,  C07C211/12 ,  C07C211/18

摘要： The invention relates to a process for preparing primary amines, which comprises hydrogenating at least one nitrile in an apparatus (V1) in the presence of an unsupported cobalt catalyst to obtain at least one primary amine, with recurrent or continuous addition of at least one compound (I) to the apparatus (V1), said compound (I) comprising at least one component selected from alkali metal, alkaline earth metal and rare earth metal.

公开(公告)号：US20170320823A1

公开(公告)日：2017-11-09

申请号：US15594795

申请日：2017-05-15

申请人： Cadila Healthcare Limited

发明人： Mukul R. Jain ,  Suresh Giri ,  Himanshu M. Kothari ,  Kaushik Banerjee ,  Rashmikant Kachhiya

IPC分类号： C07D207/333 ,  C07D233/58 ,  A61K31/155 ,  C07C279/14 ,  C07C229/26 ,  C07C217/60 ,  C07C215/40 ,  C07C215/12 ,  C07C215/10 ,  C07C211/51 ,  C07C211/35 ,  C07C211/30 ,  C07C211/27 ,  C07C211/11 ,  A61K45/06 ,  A61K38/26 ,  A61K31/64 ,  A61K31/505 ,  A61K31/4985 ,  A61K31/4015 ,  A61K31/40 ,  C07D295/027 ,  C07C2601/14

CPC分类号： C07D207/333 ,  A61K31/155 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/64 ,  A61K38/26 ,  A61K45/06 ,  A61K2300/00 ,  C07C211/11 ,  C07C211/27 ,  C07C211/30 ,  C07C211/35 ,  C07C211/51 ,  C07C215/10 ,  C07C215/12 ,  C07C215/40 ,  C07C217/60 ,  C07C229/26 ,  C07C279/14 ,  C07C2601/14 ,  C07D233/58 ,  C07D295/027

摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.

公开(公告)号：US09149531B2

公开(公告)日：2015-10-06

申请号：US14178534

申请日：2014-02-12

申请人： AXOLABS GMBH

发明人： Rainer Constien ,  Anke Geick ,  Philipp Hadwiger ,  Torsten Haneke ,  Ludger Markus Ickenstein ,  Carla Alexandra Hernandez Prata ,  Andrea Schuster ,  Timo Weide

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  A61K47/18 ,  C07C211/14 ,  C07C217/08 ,  C07C217/28 ,  A61K9/127 ,  B82Y5/00 ,  C07D241/04 ,  A61K9/14 ,  A61K31/70 ,  A61K38/02 ,  C07C211/11 ,  C07C211/13 ,  C07C211/22 ,  C07C217/42 ,  A61K31/575 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/22 ,  C07D295/30 ,  A61K39/00

CPC分类号： A61K9/145 ,  A61K9/1271 ,  A61K31/575 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  B82Y5/00 ,  C07C211/11 ,  C07C211/13 ,  C07C211/14 ,  C07C211/22 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42 ,  C07D241/04 ,  C07D295/13 ,  C07D295/30

摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

摘要翻译： 本发明提供新的氨基脂质，包含这种氨基脂质的组合物及其制备方法。 此外，提供了包含新型氨基脂质和生物活性化合物的脂质纳米粒子，以及生产方法及其用于细胞内药物递送。

公开(公告)号：US09079823B2

公开(公告)日：2015-07-14

申请号：US13982694

申请日：2012-02-03

申请人： Philippe Leconte

发明人： Philippe Leconte

IPC分类号： C07C209/48 ,  C07C253/30

CPC分类号： C07C209/48 ,  C07C253/30 ,  Y02P20/582 ,  C07C211/11 ,  C07C255/24

摘要： A continuous method (P) for preparing diamine is described. The method includes reacting the corresponding alkene nitrile with the corresponding monoamine in order to form the corresponding aminonitrile. The monoamine can be introduced in molecular excess with respect to the alkene nitrile, wherein the unreacted monoamine is recirculated to the reaction; followed by reducing the aminonitrile produced by hydrogen in the presence of at least one alkali-metal hydroxide, water, and a hydrogenation catalyst; and purifying the diamine.

摘要翻译： 描述了制备二胺的连续方法（P）。 该方法包括使相应的烯腈与相应的单胺反应以形成相应的氨基腈。 单胺可以相对于烯腈分子过量引入，其中未反应的单胺再循环到反应中; 然后在至少一种碱金属氢氧化物，水和氢化催化剂的存在下还原氢气产生的氨基腈; 并纯化二胺。

公开(公告)号：US20150050295A9

公开(公告)日：2015-02-19

申请号：US14178534

申请日：2014-02-12

申请人： AXOLABS GMBH

发明人： RAINER CONSTIEN ,  ANKE GEICK ,  PHILIPP HADWIGER ,  TORSTEN HANEKE ,  LUDGER MARKUS ICKENSTEIN ,  CARLA ALEXANDRA HERNANDEZ PRATA ,  ANDREA SCHUSTER ,  TIMO WEIDE

IPC分类号： A61K47/18 ,  A61K39/00 ,  A61K31/7088

CPC分类号： A61K9/145 ,  A61K9/1271 ,  A61K31/575 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  B82Y5/00 ,  C07C211/11 ,  C07C211/13 ,  C07C211/14 ,  C07C211/22 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42 ,  C07D241/04 ,  C07D295/13 ,  C07D295/30

摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

摘要翻译： 本发明提供新的氨基脂质，包含这种氨基脂质的组合物及其制备方法。 此外，提供了包含新型氨基脂质和生物活性化合物的脂质纳米粒子，以及生产方法及其用于细胞内药物递送。

公开(公告)号：US20060180794A1

公开(公告)日：2006-08-17

申请号：US11058007

申请日：2005-02-15

申请人： Richard Goddard ,  Michael Ford

发明人： Richard Goddard ,  Michael Ford

IPC分类号： C23F11/00

CPC分类号： C09K8/54 ,  C02F2303/08 ,  C07C211/10 ,  C07C211/11 ,  C07C229/16 ,  C07C291/04 ,  C11D3/0073 ,  C11D7/3209 ,  C11D7/3218 ,  C23F11/08 ,  C23F11/14 ,  C23F11/141 ,  C23F11/143 ,  C23F11/147 ,  C23F11/173

摘要： Compounds having N-oxide, quaternary ammonium, and/or betaine functionality according to formulas (1)-(4) are effective corrosion inhibitors, suitable for use in any of a variety of applications such as automotive cooling systems, heating boilers, drilling of oil wells, and the handling, transportation and storage of crude petroleum and various petroleum fractions. The groups R1-R5 may be certain hydrocarbyl groups. In formulas (1) and (3), R3 may also be (CH2)p—COO− in which p is either 1 or 2, and R2 may also be (CH2)p—COO− in formulas (3) and (4). In the compounds of formulas (1) and (2), R2 may also be a polyhydroxyalkyl group of formula (A), shown below.

摘要翻译： 具有式（1） - （4）的N-氧化物，季铵和/或甜菜碱功能的化合物是有效的缓蚀剂，适用于各种应用中的任何一种，如汽车冷却系统，加热锅炉， 油井，以及原油和各种石油馏分的处理，运输和储存。 基团R 1 -R 5可以是某些烃基。 在式（1）和（3）中，R 3也可以是（CH 2）2 - COO - >其中p是1或2，R 2也可以是（CH 2）2 - SUP（3）和（4））。 在式（1）和（2）的化合物中，R 2也可以是如下所示的式（A）的聚羟烷基。

公开(公告)号：US20060148893A1

公开(公告)日：2006-07-06

申请号：US10560012

申请日：2004-06-09

申请人： Jean-Baptiste Blanc ,  Rodolfo Cadilla ,  David Cowan ,  Istvan Kaldor ,  Andrew Larkin ,  Eugene Stewart ,  Ryan Trump ,  Philip Turnbull

发明人： Jean-Baptiste Blanc ,  Rodolfo Cadilla ,  David Cowan ,  Istvan Kaldor ,  Andrew Larkin ,  Eugene Stewart ,  Ryan Trump ,  Philip Turnbull

IPC分类号： A61K31/277 ,  C07C255/49

CPC分类号： C07C323/25 ,  A61K31/275 ,  C07C211/10 ,  C07C211/11 ,  C07C211/52 ,  C07C211/53 ,  C07C215/76 ,  C07C217/08 ,  C07C217/20 ,  C07C217/28 ,  C07C225/22 ,  C07C247/04 ,  C07C255/58 ,  C07C255/59 ,  C07C311/05 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

摘要： This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

摘要翻译： 本发明涉及被认为是雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的非甾类化合物，以及制备和使用这些化合物的方法。