公开(公告)号：US20240264156A1

公开(公告)日：2024-08-08

申请号：US18290827

申请日：2022-12-21

Applicant: Aalto University Foundation sr

Inventor： Jacky Loo ,  Yike Huang ,  Minh-Kha Nguyen ,  Susanna Hällsten ,  Anton Kuzyk ,  Tim Liedl

IPC: G01N33/543 ,  G01N21/552

CPC classification number: G01N33/54346 ,  G01N21/554 ,  G01N33/54386

Abstract: The present invention is directed to a nanoscaled construct, said construct comprising or essentially consisting of a nucleic acid structure with reconfigurable or switchable features, and at least two separate metallic nanoparticles coupled with said nucleic acid structure, wherein said two separate nanoparticles are at an interchangeable angle to each other, wherein said nanoparticles provide high chirality and/or optical activity within the visible and near-infrared (NIR) spectrum from 400 to 800 nm generating a color for the construct, and wherein said construct has an absorption dissymmetry factor (g-factor) of over 10%. There is also provided a method for detecting an analyte in a sample, the method comprising steps of contacting a nanoscaled construct of the present disclosure specific to said analyte with a sample in a test assay, and detecting said analyte in said sample by optical means or by naked eye, wherein the presence of the analyte in said sample changes the color of said nanoscaled structure and the change of color in said assay confirms the presence of the analyte in said sample.