公开(公告)号：US12078595B2

公开(公告)日：2024-09-03

申请号：US16844707

申请日：2020-04-09

申请人： The University of North Carolina at Greensboro

发明人： Jianjun Wei

IPC分类号： G01N21/552 ,  B01L3/00 ,  G01N21/64 ,  G01N33/574

CPC分类号： G01N21/554 ,  B01L3/502715 ,  G01N21/6458 ,  G01N33/57488 ,  B01L2300/0627 ,  B01L2300/0887 ,  B01L2300/0896 ,  G01N2201/06113 ,  G01N2201/12

摘要： In one aspect, nanoplasmonic devices are described herein. In some embodiments, a nanoplasmonic device comprises a radiation transmissive substrate, a metal layer positioned on the substrate and at least one aperture extending through the metal layer to the radiation transmissive substrate, wherein width of the aperture decreases with increasing depth of the aperture.

公开(公告)号：US12078537B2

公开(公告)日：2024-09-03

申请号：US18549489

申请日：2022-03-01

申请人： Nicoya Lifesciences Inc.

发明人： Udayan Kanade ,  Sanat Ganu

IPC分类号： G01J3/28 ,  G01N21/552

CPC分类号： G01J3/28 ,  G01N21/554 ,  G01J2003/2859

摘要： A system and method for fording the peak wavelength of the spectrum sensed by an LSPR spectrometer is described herein. The method comprises reading an image representing the reflected/absorbed spectrum, using a mathematical model of the LSPR spectrometer system to estimate a parametric curve representing the absorbance/reflectance spectrum, and adjusting or optimizing the parameters of the parametric curve so as to increase the likelihood of the parametric curve representing the sensed spectrum. Also described herein is a novel method to achieve LSPR peak wavelength signal noise reduction using an adaptive regularization algorithm.

公开(公告)号：US20240241052A1

公开(公告)日：2024-07-18

申请号：US18560188

申请日：2021-06-09

申请人： SUN YAT-SEN UNIVERSITY

发明人： Chongjun JIN ,  Yang SHEN ,  Kai HE ,  Shan XING

IPC分类号： G01N21/552 ,  G01N21/01 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N21/554 ,  G01N21/01 ,  G01N33/54373 ,  G01N33/689 ,  G01N2021/0112 ,  G01N2333/471 ,  G01N2800/385

摘要： A biosensor for implementing an FP-WA coupled mode includes a dielectric layer and a metal layer. The dielectric layer includes a plurality of dielectric grooves, and the plurality of dielectric grooves are periodically distributed at equal intervals. An opening width of the dielectric groove gradually decreases in a direction from a groove opening to a groove bottom. The metal layer is disposed on the dielectric layer and includes metal grooves that are in one-to-one correspondence with the dielectric grooves.

公开(公告)号：US12007326B2

公开(公告)日：2024-06-11

申请号：US17471951

申请日：2021-09-10

申请人： CreeLED, Inc.

发明人： Michael Check ,  David Suich ,  Steven Wuester

IPC分类号： G01N21/552 ,  B82Y30/00 ,  H01L33/50 ,  H01L33/56

CPC分类号： G01N21/554 ,  H01L33/502 ,  H01L33/56 ,  B82Y30/00

摘要： Lumiphoric materials and corresponding light-emitting devices, and more particularly localized surface plasmon resonance for enhanced photoluminescence of lumiphoric materials are disclosed. Plasmonic materials are disclosed that are configured to induce localized surface plasmon resonance and excite a corresponding localized surface plasmon enhanced electric field in response to incident light. An increase in photoluminescence of lumiphoric materials may be realized when the lumiphoric materials are arranged within the localized surface plasmon enhanced electric field. Plasmonic materials are disclosed that include various arrangements of nanoparticles and/or patterned structures with corresponding dielectric materials that are collectively arranged in close proximity to lumiphoric materials.

公开(公告)号：US20240077409A1

公开(公告)日：2024-03-07

申请号：US18070441

申请日：2022-11-28

申请人： GUANGZHOU LUXVISIONS INNOVATION TECHNOLOGY LIMITED

发明人： Tzu-Yao Lin ,  Shih-Chieh Yen

IPC分类号： G01N21/21 ,  G01N21/27 ,  G01N21/33 ,  G01N21/3563 ,  G01N21/552

CPC分类号： G01N21/21 ,  G01N21/27 ,  G01N21/33 ,  G01N21/3563 ,  G01N21/554 ,  G01N2021/216

摘要： A chiral molecule detector includes a light source, a photodetector, and a carrier. The carrier is configured to reflect at least part of light emitted by the light source to the photodetector. The carrier includes a substrate and a metal reflective layer. An upper surface of the substrate has a periodic hole array containing multiple holes. The metal reflective layer is located on the upper surface of the substrate, and covers a sidewall of the hole and a bottom surface of the hole.

公开(公告)号：US11898957B2

公开(公告)日：2024-02-13

申请号：US17197805

申请日：2021-03-10

申请人： Jay James ,  Jeffrey Scott Crosby

发明人： Jay James ,  Jeffrey Scott Crosby

IPC分类号： G01N21/552 ,  G01N33/00

CPC分类号： G01N21/554 ,  G01N33/0045

摘要： Apparatus and methods are provided for quantitative detection of mercury vapor in gas samples using a film of nanoparticles. The localized surface plasmon resonance (LSPR) of an amalgam nanoparticle is sensitive to adsorbed mercury mass. The equilibrium mass of mercury on a gold nanoparticle is a function of the surrounding vapor concentration and the temperature of the gold. A device that introduces a temperature-controlled gold nanoparticle film to a controlled flow of sample gas responds predictably to a given mercury vapor concentration when optically probed in situ. Controlling the temperature of the film allows for control of adsorption and desorption rates. Equilibrium plasmonic mercury detection, described herein, removes the cycling necessary for many gold-based mercury analyses. Methods are given for the operation and analysis of the temperature-stabilized gold nanoparticle mercury sensor. The disclosed mercury-detection apparatus and methods find use in a variety of applications, including, for example, mercury detecting applications.

公开(公告)号：US20240044888A1

公开(公告)日：2024-02-08

申请号：US17931769

申请日：2022-09-13

申请人： Rafael Biotechnology Company Limited

发明人： Siu Pang Ng

IPC分类号： G01N33/543 ,  G01N21/552

CPC分类号： G01N33/54373 ,  G01N21/554

摘要： A thermo-plasmonic biochip, a manufacturing method thereof, a biosensing system containing the thermo-plasmonic biochip and an application thereof are disclosed. The biochip includes a first component and a second component, substrates of which both include a recess, a plurality of flow cells arranged on a bottom surface of the recess at intervals, a conical waveguide longitudinally arranged in the flow cells, and TiN nanocubes arranged on a conical surface of the conical waveguide. The first component further includes a sample inlet hole and a sample outlet hole communicated with the recess; and composition materials of the first component and the second component contain crystal violet.

公开(公告)号：US20240027439A1

公开(公告)日：2024-01-25

申请号：US18376380

申请日：2023-10-03

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Amogha TADIMETY ,  John X.J. ZHANG

IPC分类号： G01N33/543 ,  G01N21/552 ,  G01N33/553

CPC分类号： G01N33/54373 ,  G01N21/554 ,  G01N33/54346 ,  G01N33/553 ,  B82Y15/00

摘要： A method of making a plasmon-resonance biosensor includes conjugating precious metal nanorods with form factor at least 1.5 with a biological probe material. Microfluidic chambers of volume under 0.025 microliter are formed over a substrate, and an aqueous suspension of the conjugated nanorods is injected into the chambers. The nanorods are organized in rows and aligned in long dimension along the rows. The biosensor is configured to be read by obtaining an optical absorption spectrum upon exposure to the analyte. The biosensor includes precious metal nanorods organized in rows with long dimension approximately parallel to the rows. The nanorods are conjugated with biological probes capable of binding to an analyte, the probes may be an aptamer, an antibody, a protein-nucleic acid (PNA), a complimentary DNA, or an enzyme having a binding site.

公开(公告)号：US20240003869A1

公开(公告)日：2024-01-04

申请号：US18255377

申请日：2021-11-10

申请人： IZMIR BIYOTIP VE GENOM MERKEZI

发明人： Arif Engin CETIN

IPC分类号： G01N33/50 ,  G01N21/552

CPC分类号： G01N33/5011 ,  G01N21/554

摘要： A plasmonic-based biosensor platform that determines the biophysical properties of cells, the changes within, and their therapeutic behavior upon the molecules that cause these changes in an ex vivo and label-free manner is provided. The plasmonic-based biosensor platform includes a plasmonic chip, a light source, an inverted microscope, an incubator case, an optical read-out device, and a graphical user interface. The biosensor platform of the invention could determine the therapeutic susceptibility of cancer cells to cancer drugs in a label-free manner.

公开(公告)号：US20230417667A1

公开(公告)日：2023-12-28

申请号：US18035202

申请日：2021-11-01

申请人： The General Hospital Corporation ,  Korea Advanced Institute of Science and Technology

发明人： Hakho Lee ,  Hyungsoon Im ,  Nam Ho Bae ,  Seok Jae Lee ,  Kyoung Gyun Lee ,  Kwang Hee Kim ,  Kil Sun Roh

IPC分类号： G01N21/552 ,  G01N21/41

CPC分类号： G01N21/554 ,  G01N21/41 ,  G01N2021/5903

摘要： Methods, systems, and apparatus, for a sensor-chip device for performing analysis on target substances. In one aspect, the sensor-chip assembly includes a chip body including a substrate, at least one metal layer formed on the substrate, and nanoholes formed in the metal layer, a base having an accommodating portion for accommodating the chip body, and a fixing member fixing the chip body accommodated in the accommodating portion by being coupled to the base.