公开(公告)号：US20230183236A1

公开(公告)日：2023-06-15

申请号：US17995874

申请日：2021-04-09

Applicant: AbbVie Inc.

Inventor： Rodger F. Henry ,  Yi SHI ,  Geoff Zhang ,  Devalina Law

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07B2200/13

Abstract: Crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (Venetoclax) are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.