公开(公告)号：US10131657B2

公开(公告)日：2018-11-20

申请号：US14392200

申请日：2014-05-13

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  C07D471/04 ,  A61K45/06 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/497 ,  A61K31/506

Abstract: The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20160185769A1

公开(公告)日：2016-06-30

申请号：US14392200

申请日：2014-05-13

Applicant: ABBVIE INC.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: C07D471/04 ,  A61K31/541 ,  A61K31/496 ,  A61K31/551 ,  A61K31/437 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

Abstract: The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物。 其中Rx，Ry，Rx1，L1，G1，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症 疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。

公开(公告)号：US20190084981A1

公开(公告)日：2019-03-21

申请号：US16192927

申请日：2018-11-16

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: C07D471/04 ,  A61K45/06 ,  A61K31/506 ,  A61K31/497 ,  A61K31/437 ,  A61K31/551 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545

Abstract: The present invention provides for compounds of formula (I) wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US09957263B2

公开(公告)日：2018-05-01

申请号：US14392201

申请日：2014-06-27

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: C07D471/02 ,  A61K31/44 ,  A61K31/497 ,  C07D471/04 ,  A61K45/06 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/4545 ,  A61K31/506

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.

公开(公告)号：US20160272630A1

公开(公告)日：2016-09-22

申请号：US14392201

申请日：2014-06-27

Applicant: ABBVIE INC.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: C07D471/04 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/497 ,  A61K31/506 ,  A61K31/551 ,  A61K31/437 ,  A61K31/496

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.