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公开(公告)号：US11786519B2
公开(公告)日：2023-10-17
申请号：US17022693
申请日：2020-09-16
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20220017511A1
公开(公告)日：2022-01-20
申请号：US17183832
申请日：2021-02-24
Applicant: AbbVie Inc.
Inventor： Steven D. Fidanze , Lisa A. Hasvold , Dachun Liu , Keith F. McDaniel , John Pratt , Michael Schrimpf , George Sheppard , Le Wang , Bing Li
IPC: C07D471/04
Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US20210047304A1
公开(公告)日：2021-02-18
申请号：US16883713
申请日：2020-05-26
Applicant: AbbVie Inc.
Inventor： Marlon Cowart , Steven Fidanze , Lisa Hasvold , Dachun Liu , Keith McDaniel , John Pratt , George Sheppard , Le Wang
IPC: C07D405/12 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/10
Abstract: The present invention provides for compounds of formula (I) wherein R1, Y, L1, G1, X1, X2, L2, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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4.发明申请公开(公告)号：US20180140595A1
公开(公告)日：2018-05-24
申请号：US15803568
申请日：2017-11-03
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , C07D401/04 , C07D417/14 , C07D487/04 , C07D493/08 , C07D513/04 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D471/04 , A61K31/541
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US09957263B2
公开(公告)日：2018-05-01
申请号：US14392201
申请日：2014-06-27
Applicant: AbbVie Inc.
Inventor： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC: C07D471/02 , A61K31/44 , A61K31/497 , C07D471/04 , A61K45/06 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/4545 , A61K31/506
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
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Patent Agency Ranking
公开(公告)号：US09844547B2
公开(公告)日：2017-12-19
申请号：US14961748
申请日：2015-12-07
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/54 , A61K31/4725 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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7.发明申请公开(公告)号：US20170158666A1
公开(公告)日：2017-06-08
申请号：US15219208
申请日：2016-07-25
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20160272630A1
公开(公告)日：2016-09-22
申请号：US14392201
申请日：2014-06-27
Applicant: ABBVIE INC.
Inventor： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC: C07D471/04 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/437 , A61K31/496
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Pharmaceutical compositions comprised of one or more compounds of formula (I) are also provided.
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9.发明申请公开(公告)号：US20160206611A1
公开(公告)日：2016-07-21
申请号：US14994824
申请日：2016-01-13
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , A61K31/5377 , C07D417/14
CPC classification number: A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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10.发明授权公开(公告)号：US09266877B2
公开(公告)日：2016-02-23
申请号：US14559828
申请日：2014-12-03
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: C07D417/14 , A61K31/4725 , A61K31/5377 , A61K45/06
CPC classification number: A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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