公开(公告)号：US20160060228A1

公开(公告)日：2016-03-03

申请号：US14937262

申请日：2015-11-10

Applicant: AbbVie Inc.

Inventor： Jean-Christophe Califano ,  James J. Napier ,  Calvin L. Becker ,  Su Yu

IPC: C07D239/54 ,  C07F7/08

CPC classification number: C07D239/54 ,  C07C311/08 ,  C07F7/0812

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

Abstract translation: 本发明涉及：（a）制备其特别是可用于抑制丙型肝炎病毒（HCV）的化合物及其盐的方法; （b）可用于制备化合物和盐的中间体; （c）包含该化合物或其盐的药物组合物; 和（d）使用这种组合物的方法。

公开(公告)号：US20150239882A1

公开(公告)日：2015-08-27

申请号：US14707681

申请日：2015-05-08

Applicant: AbbVie Inc.

Inventor： Shuang Chen ,  James J. Napier ,  Geoff G.Z. Zhang ,  Paul J. Brackemeyer

IPC: C07D451/14 ,  A61K45/06 ,  A61K31/439

CPC classification number: C07D451/14 ,  A61K31/439 ,  A61K45/06 ,  C07D471/08

Abstract: The invention relates to a crystalline monohydrate of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane dihydrogen citrate, compositions comprising such compound, and a process for preparing such compound.

Abstract translation: 本发明涉及（4s）-4-（5-苯基-1,3,4-噻二唑-2-基氧基）-1-氮杂三环[3.3.1.13,7]癸烷二氢二氢柠檬酸盐的结晶一水合物，包含这种化合物 ，以及这种化合物的制备方法。

公开(公告)号：US09802903B2

公开(公告)日：2017-10-31

申请号：US14937262

申请日：2015-11-10

Applicant: AbbVie Inc.

Inventor： Jean-Christophe Califano ,  James J. Napier ,  Calvin L. Becker ,  Su Yu

IPC: C07D239/54 ,  C07C311/08 ,  C07F7/08

CPC classification number: C07D239/54 ,  C07C311/08 ,  C07F7/0812

Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.