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公开(公告)号:US09802903B2
公开(公告)日:2017-10-31
申请号:US14937262
申请日:2015-11-10
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , James J. Napier , Calvin L. Becker , Su Yu
IPC: C07D239/54 , C07C311/08 , C07F7/08
CPC classification number: C07D239/54 , C07C311/08 , C07F7/0812
Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.
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公开(公告)号:US09593078B2
公开(公告)日:2017-03-14
申请号:US14707433
申请日:2015-05-08
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , Michael G. Fickes , Lars Fredrik Nordstroem
IPC: C07D401/14 , C07D207/16 , C07D405/14 , C07D413/14 , A61K38/05 , A61K31/4178 , C07D401/10 , C07D403/14 , C07D417/14 , C07D519/00
CPC classification number: C07D207/16 , A61K31/4178 , A61K38/05 , C07D401/10 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D519/00
Abstract: The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern as shown in one of FIGS. 1-10.
Abstract translation: 本发明的特征在于化合物I的结晶形式。在一个实施方案中,化合物I的结晶形式在PXRD图案中具有特征峰,如图1和图2之一所示。 1-10。
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公开(公告)号:US20160090373A1
公开(公告)日:2016-03-31
申请号:US14867785
申请日:2015-09-28
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , Michael G. Fickes , Lars F. Nordstroem
IPC: C07D401/14
CPC classification number: C07D401/14
Abstract: Disclosed are crystalline forms of a compound of formula (I), methods of their preparation, and related pharmaceutical preparations thereof.
Abstract translation: 公开了式(I)化合物的结晶形式,其制备方法及其相关药物制剂。
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公开(公告)号:US20150322047A1
公开(公告)日:2015-11-12
申请号:US14707433
申请日:2015-05-08
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , Michael G. Fickes , Lars Fredrik Nordstroem
IPC: C07D403/14
CPC classification number: C07D207/16 , A61K31/4178 , A61K38/05 , C07D401/10 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D519/00
Abstract: The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern as shown in one of FIGS. 1-10.
Abstract translation: 本发明的特征在于化合物I的结晶形式。在一个实施方案中,化合物I的结晶形式在PXRD图案中具有特征峰,如图1和图2之一所示。 1-10。
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公开(公告)号:USRE48923E1
公开(公告)日:2022-02-08
申请号:US15830544
申请日:2017-12-04
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , Michael G. Fickes , Lars Fredrik Nordstroem
IPC: C07D401/14 , C07D207/16 , C07D405/14 , C07D413/14 , A61K38/05 , A61K31/4178 , C07D401/10 , C07D403/14 , C07D417/14 , C07D519/00
Abstract: The present invention features crystalline forms of Compound I. In one embodiment, a crystalline form of Compound I has characteristic peaks in the PXRD pattern as shown in one of FIGS. 1-10.
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公开(公告)号:US20160060228A1
公开(公告)日:2016-03-03
申请号:US14937262
申请日:2015-11-10
Applicant: AbbVie Inc.
Inventor: Jean-Christophe Califano , James J. Napier , Calvin L. Becker , Su Yu
IPC: C07D239/54 , C07F7/08
CPC classification number: C07D239/54 , C07C311/08 , C07F7/0812
Abstract: This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.
Abstract translation: 本发明涉及:(a)制备其特别是可用于抑制丙型肝炎病毒(HCV)的化合物及其盐的方法; (b)可用于制备化合物和盐的中间体; (c)包含该化合物或其盐的药物组合物; 和(d)使用这种组合物的方法。
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公开(公告)号:US09238652B2
公开(公告)日:2016-01-19
申请号:US14637639
申请日:2015-03-04
Applicant: AbbVie Inc.
Inventor: Jufang Barkalow , Jean-Christophe Califano , Vincent S. Chan , Alan C. Christesen , Timothy A. Grieme , Yi-Yin Ku , Mathew M. Mulhern , Yu-Ming M. Pu
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
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公开(公告)号:US20150252042A1
公开(公告)日:2015-09-10
申请号:US14637639
申请日:2015-03-04
Applicant: AbbVie Inc.
Inventor: Jufang Barkalow , Jean-Christophe Califano , Vincent S. Chan , Alan C. Christesen , Timothy A. Grieme , Yi-Yin Ku , Mathew M. Mulhern , Yu-Ming M. Pu
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
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