公开(公告)号：US20180243298A1

公开(公告)日：2018-08-30

申请号：US15563888

申请日：2016-03-30

Applicant: AbbVie Inc.

Inventor： Lawrence Black ,  Brian S. Brown ,  Bruce Clapham ,  Marlon D. Cowart ,  Michael J. Dart ,  Ramin Faghih ,  Jennifer Frost ,  Arthur R. Gomtsyan ,  Philip R. Kym ,  Huaqing Liu ,  Robert G. Schmidt ,  Lei Shi ,  Anurupa Shrestha ,  Kevin Sippy

IPC: A61K31/506 ,  A61P17/06 ,  A61P17/04

CPC classification number: A61K31/506 ,  A61P17/04 ,  A61P17/06 ,  C07D417/12 ,  C07D417/14 ,  C07D491/048 ,  C07D491/107

Abstract: A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.