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1.发明授权6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use 有权6-芳基氧基 - 或6-芳氧基 - 喹啉-2-甲酰胺及其使用方法公开(公告)号：US09452986B2
公开(公告)日：2016-09-27
申请号：US14613579
申请日：2015-02-04
Applicant: AbbVie Inc.
Inventor： Andrew Bogdan , Marlon D. Cowart , David A. DeGoey , Tammie K. Jinkerson , John R. Koenig , Michael E. Kort , Bo Liu , Mark A. Matulenko , Derek W. Nelson , Meena V. Patel , Hillary Peltier , Marc J. Scanio , Brian D. Wakefield
IPC: C07D215/48 , C07D401/12 , C07D409/14 , C07D487/08 , C07D401/14 , C07D487/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D405/12 , C07D409/12 , C07D417/12
CPC classification number: C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US20180334435A1
公开(公告)日：2018-11-22
申请号：US15952682
申请日：2018-04-13
Applicant: AbbVie Inc.
Inventor： Andrew Bogdan , Marlon D. Cowart , David A. DeGoey , Tammie K. Jinkerson , John R. Koenig , Michael E. Kort , Bo Liu , Mark A. Matulenko , Derek W. Nelson , Meena V. Patel , Hillary Peltier , Marc J. Scanio , Brian D. Wakefield
IPC: C07D215/48 , C07D487/04 , C07D405/12 , C07D487/08 , C07D401/12 , C07D471/04 , C07D417/14 , C07D405/14 , C07D409/14 , C07D401/14 , C07D409/12 , C07D417/12
CPC classification number: C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US20180243298A1
公开(公告)日：2018-08-30
申请号：US15563888
申请日：2016-03-30
Applicant: AbbVie Inc.
Inventor： Lawrence Black , Brian S. Brown , Bruce Clapham , Marlon D. Cowart , Michael J. Dart , Ramin Faghih , Jennifer Frost , Arthur R. Gomtsyan , Philip R. Kym , Huaqing Liu , Robert G. Schmidt , Lei Shi , Anurupa Shrestha , Kevin Sippy
IPC: A61K31/506 , A61P17/06 , A61P17/04
CPC classification number: A61K31/506 , A61P17/04 , A61P17/06 , C07D417/12 , C07D417/14 , C07D491/048 , C07D491/107
Abstract: A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
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公开(公告)号：US20170226062A9
公开(公告)日：2017-08-10
申请号：US15239554
申请日：2016-08-17
Applicant: AbbVie Inc.
Inventor： Andrew Bogdan , Marlon D. Cowart , David A. DeGoey , Tammie K. Jinkerson , John R. Koenig , Michael E. Kort , Bo Liu , Mark A. Matulenko , Derek W. Nelson , Meena V. Patel , Hillary Peltier , Marc J. Scanio , Brian D. Wakefield
IPC: C07D215/48 , C07D409/14 , C07D487/08 , C07D471/04 , C07D487/04 , C07D405/14 , C07D417/14 , C07D401/12 , C07D401/14
CPC classification number: C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US20160130282A1
公开(公告)日：2016-05-12
申请号：US14934510
申请日：2015-11-06
Applicant: AbbVie Inc.
Inventor： Marlon D. Cowart , Huaqing Liu , Robert Altenbach
IPC: C07D513/04
CPC classification number: C07D513/04
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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Patent Agency Ranking
公开(公告)号：US10508113B2
公开(公告)日：2019-12-17
申请号：US16299485
申请日：2019-03-12
Applicant: AbbVie Inc.
Inventor： Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher
IPC: C07D405/14 , C07D471/04
Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, nad n are as defined herein, pharmaeceutical compositions 2C X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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7.发明申请6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE 有权6-异亮氨酸或6-芳基喹啉-2-羧酸酰胺及其使用方法公开(公告)号：US20160355482A1
公开(公告)日：2016-12-08
申请号：US15239554
申请日：2016-08-17
Applicant: AbbVie Inc.
Inventor： Andrew Bogdan , Marlon D. Cowart , David A. DeGoey , Tammie K. Jinkerson , John R. Koenig , Michael E. Kort , Bo Liu , Mark A. Matulenko , Derek W. Nelson , Meena V. Patel , Hillary Peltier , Marc J. Scanio , Brian D. Wakefield
IPC: C07D215/48 , C07D409/14 , C07D487/08 , C07D471/04 , C07D487/04 , C07D405/14 , C07D417/14 , C07D401/12 , C07D401/14
CPC classification number: C07D215/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
Abstract translation: 和其药学上可接受的盐，酯，酰胺或放射性标记形式，其中R1，R2和R3如说明书中所定义，可用于治疗由电压门控钠通道（例如Nav1）预防或改善的病症或病症。 7和/或Nav1.8。 公开了制备化合物的方法。 还公开了式（I）化合物的药物组合物，以及使用这些化合物和组合物的方法。
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公开(公告)号：US20160089378A1
公开(公告)日：2016-03-31
申请号：US14881080
申请日：2015-10-12
Applicant: AbbVie Inc.
Inventor： Marlon D. Cowart , Gin C. Hsieh , Jorge D. Brioni , James P. Sullivan
IPC: A61K31/551 , A61K31/454 , A61K31/496 , A61K31/55 , A61K31/4545 , A61K31/501 , A61K31/4025
CPC classification number: A61K31/551 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/425 , A61K31/428 , A61K31/4375 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/55
Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
Abstract translation: 本发明公开了一种通过施用本文所述的组胺H3受体拮抗剂，其盐或包含该化合物或盐的组合物治疗骨关节炎疼痛的方法。
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公开(公告)号：US20200255423A1
公开(公告)日：2020-08-13
申请号：US16654219
申请日：2019-10-16
Applicant: AbbVie Inc.
Inventor： Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher , Theresa A. Dunstan , David A. Schiedler
IPC: C07D471/04 , C07D487/04
Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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公开(公告)号：US20190276450A1
公开(公告)日：2019-09-12
申请号：US16299485
申请日：2019-03-12
Applicant: AbbVie Inc.
Inventor： Maria A. Argiriadi , Eric C. Breinlinger , Ellen Yulin Tsai Chien , Marlon D. Cowart , Kristine E. Frank , Michael M. Friedman , David J. Hardee , J. Martin Herold , Huaqing Liu , Wei Qiu , Marc J. Scanio , Michael R. Schrimpf , Thomas R. Vargo , Stacy A. Van Epps , Matthew P. Webster , Andrew J. Little , Matthew H. Katcher
IPC: C07D471/04
Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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