公开(公告)号：US09469689B2

公开(公告)日：2016-10-18

申请号：US14798849

申请日：2015-07-14

Applicant: AbbVie Inc.

Inventor： Ming-Jiu Chen ,  Chung-Ming Hsieh ,  Jijie Gu ,  Susan E. Morgan-Lappe ,  Yingchun Li

IPC: C07K16/00 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

公开(公告)号：US20190315855A1

公开(公告)日：2019-10-17

申请号：US15582112

申请日：2017-04-28

Applicant: AbbVie Inc.

Inventor： Ming-Jiu Chen ,  Chung-Ming Hsieh ,  Jije Gu ,  Susan Morgan-Lappe ,  Yingchun Li

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

公开(公告)号：US20210009681A1

公开(公告)日：2021-01-14

申请号：US16785376

申请日：2020-02-07

Applicant: AbbVie Inc.

Inventor： Ming-Jiu Chen ,  Chung-Ming Hsieh ,  Jije Gu ,  Susan Morgan-Lappe ,  Yingchun Li

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.