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公开(公告)号：US20140033504A1
公开(公告)日：2014-02-06
申请号：US14053019
申请日：2013-10-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Cameron K. Kerrigan
IPC: A61F2/91
CPC classification number: A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61F2250/0068 , B33Y80/00 , Y10T29/49826
Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.
Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。
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公开(公告)号：US09439792B2
公开(公告)日：2016-09-13
申请号：US14053019
申请日：2013-10-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Cameron K. Kerrigan
CPC classification number: A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2210/0076 , A61F2230/0013 , A61F2250/0068 , B33Y80/00 , Y10T29/49826
Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.
Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。
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公开(公告)号：US09610386B2
公开(公告)日：2017-04-04
申请号：US14515448
申请日：2014-10-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Cameron K. Kerrigan , Stephen D. Pacetti
CPC classification number: A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
Abstract: A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
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公开(公告)号：US20150030758A1
公开(公告)日：2015-01-29
申请号：US14515448
申请日：2014-10-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Cameron K. Kerrigan , Stephen D. Pacetti
CPC classification number: A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
Abstract: A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
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