公开(公告)号：US20140212476A1

公开(公告)日：2014-07-31

申请号：US14227589

申请日：2014-03-27

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Dariush Davalian ,  John Stankus ,  Yuet Mei Khong ,  O. Mikael Trollsas ,  Syed F.A. Hossainy

IPC: A61K9/127 ,  A61K31/439 ,  A61K47/48 ,  A61K41/00

CPC classification number: A61K9/127 ,  A61K9/107 ,  A61K9/1273 ,  A61K31/439 ,  A61K47/6911

Abstract: This invention relates to the targeted delivery of hydrophobic drugs or combinations of hydrophobic drugs with photodynamic therapy agents to vascular lesions by complexation of the drugs to blood serum lipoproteins, which have an affinity for and accumulate in such vascular lesions.

Abstract translation: 本发明涉及疏水性药物或疏水性药物与光动力治疗剂的组合的靶向递送，其通过使药物与血清脂蛋白的复合而形成，所述血清脂蛋白与这种血管病变具有亲和力并且积聚在血管损伤中。