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1.发明申请Heparin/Heparan Sulfate-Dependent Inhibitors of Activated Protein C and Uses Thereof in Treating Hemophilic Disorders 有权活化蛋白C的肝素/肝素硫酸依赖性抑制剂及其在治疗嗜血性疾病中的用途公开(公告)号：US20140142040A1
公开(公告)日：2014-05-22
申请号：US14081427
申请日：2013-11-15
Applicant: Academia Sinica
Inventor： Inn-Ho Tsai , An-Chun Cheng
IPC: C07K14/81
CPC classification number: C07K14/8114 , A61K38/00 , C07K14/463
Abstract: Methods for inhibiting activated protein C (APC) comprising contacting the APC with a Kunitz polypeptide in an amount effective in inhibiting the activity of APC, wherein the Kunitz polypeptide comprises six cysteine residues at positions corresponding to positions 7, 16, 32, 40, 53, and 57 in SEQ ID NO:1, a motif X1GX2CBX′ at positions corresponding to positions 13-18 in SEQ ID NO:1, wherein each of X1 and X2, independently, is any amino acid residue, B is a basic amino acid residue, and X′ is G, A, or V; and at least one heparin-binding motif, which can present at the C-terminus of the Kunitz polypeptide.
Abstract translation: 抑制活化蛋白C（APC）的方法包括以有效抑制APC活性的量使APC与Kunitz多肽接触，其中Kunitz多肽在对应于7,16,32,40,53位的位置包含6个半胱氨酸残基 ，57个，SEQ ID NO：1中的57个，在对应于SEQ ID NO：1中13-18位的位置上的基序X1GX2CBX'，其中X1和X2各自独立地是任何氨基酸残基，B是碱性氨基酸 残基，X'为G，A或V; 和至少一种肝素结合基序，其可以存在于Kunitz多肽的C末端。
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2.发明授权Heparin/heparan sulfate-dependent inhibitors of activated protein C and uses thereof in treating hemophilic disorders 有权活化蛋白C的肝素/硫酸乙酰肝素依赖性抑制剂及其在治疗嗜血性疾病中的用途公开(公告)号：US09206246B2
公开(公告)日：2015-12-08
申请号：US14081427
申请日：2013-11-15
Applicant: Academia Sinica
Inventor： Inn-Ho Tsai , An-Chun Cheng
CPC classification number: C07K14/8114 , A61K38/00 , C07K14/463
Abstract: Methods for inhibiting activated protein C (APC) comprising contacting the APC with a Kunitz polypeptide in an amount effective in inhibiting the activity of APC, wherein the Kunitz polypeptide comprises six cysteine residues at positions corresponding to positions 7, 16, 32, 40, 53, and 57 in SEQ ID NO:1, a motif X1GX2CBX′ at positions corresponding to positions 13-18 in SEQ ID NO:1, wherein each of X1 and X2, independently, is any amino acid residue, B is a basic amino acid residue, and X′ is G, A, or V; and at least one heparin-binding motif, which can present at the C-terminus of the Kunitz polypeptide.
Abstract translation: 抑制活化蛋白C（APC）的方法包括以有效抑制APC活性的量使APC与Kunitz多肽接触，其中Kunitz多肽在对应于7,16,32,40,53位的位置包含6个半胱氨酸残基 ，57个，SEQ ID NO：1中的57个，在对应于SEQ ID NO：1中13-18位的位置上的基序X1GX2CBX'，其中X1和X2各自独立地是任何氨基酸残基，B是碱性氨基酸 残基，X'为G，A或V; 和至少一种肝素结合基序，其可以存在于Kunitz多肽的C末端。
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