公开(公告)号：US12129273B2

公开(公告)日：2024-10-29

申请号：US18227782

申请日：2023-07-28

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Jim-Min Fang ,  Cheng-Han Lee ,  Jen-Yao Chang

IPC: C07H19/16 ,  A61K31/7076 ,  A61K38/04 ,  A61K47/55 ,  A61P29/00

CPC classification number: C07H19/16 ,  A61K31/7076 ,  A61K38/046 ,  A61K47/55 ,  A61P29/00

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US11753432B2

公开(公告)日：2023-09-12

申请号：US16481042

申请日：2018-01-26

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Jim-Min Fang ,  Cheng-Han Lee ,  Jen-Yao Chang

IPC: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/04

CPC classification number: C07H19/16 ,  A61K31/7076 ,  A61K38/046 ,  A61K47/55 ,  A61P29/00

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-O-(glycine-N-carbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5-deoxy-5′-(glycine-N-amido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.