公开(公告)号：US20230381761A1

公开(公告)日：2023-11-30

申请号：US18030773

申请日：2021-10-07

Applicant: Academia Sinica

Inventor： Shang-Cheng HUNG ,  Chi-Huey WONG ,  Veeranjaneyulu GANNEDI ,  Bharath Kumar VILLURI ,  Nimmakayala Sivakumar REDDY ,  Chiao-Chu KU

IPC: B01J31/02 ,  C07H1/02 ,  C07H7/06

CPC classification number: B01J31/0245 ,  C07H1/02 ,  C07H7/06

Abstract: Disclosed herein are novel catalysts for producing remdesivir in one-pot manner, in which a diastereomerically enriched form of an intermediate, which following acidic hydrolysis would give rise to the desired remdesivir, was produced with the aid of the disclosed novel catalysts. Also disclosed herein is an improved process for the preparation of remdesivir without the need to separate one of the enantiomers while minimizing the formation of undesired isomers, thus offers economic advantages for operation on a commercial scale.