公开(公告)号：US20210355207A1

公开(公告)日：2021-11-18

申请号：US16978278

申请日：2019-03-05

Applicant: Academia Sinica

Inventor： Chih-Cheng CHEN ,  Yu-Chia CHUANG

IPC: C07K16/28 ,  A61K45/06 ,  A61K31/485 ,  A61K31/195 ,  A61K31/135 ,  A61P25/00

Abstract: Disclosed herein are method and/or kit for rendering a diagnosis on whether a subject is suffering from peripheral neuropathy pain. The method comprises detecting the presence of advillin in a biological sample by forming an immune complex between advillin and a monoclonal antibody specifically binds thereto. Also disclosed herein is a method of treating a subject suffering from peripheral neuropathy pain.

公开(公告)号：US20190389898A1

公开(公告)日：2019-12-26

申请号：US16481042

申请日：2018-01-26

Applicant: Academia Sinica

Inventor： Chih-Cheng CHEN ,  Jim-Min FANG ,  Cheng-Han LEE ,  Jen-Yao CHANG

IPC: C07H19/16 ,  A61P29/00 ,  A61K38/04 ,  A61K47/55 ,  A61K31/7076

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US20240010669A1

公开(公告)日：2024-01-11

申请号：US18227782

申请日：2023-07-28

Applicant: Academia Sinica

Inventor： Chih-Cheng CHEN ,  Jim-Min FANG ,  Cheng-Han LEE ,  Jen-Yao CHANG

IPC: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/04

CPC classification number: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/046

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.