公开(公告)号：US20230201359A1

公开(公告)日：2023-06-29

申请号：US17927743

申请日：2021-05-26

Applicant: Academia Sinica

Inventor： PATRICK CH HSIEH ,  HSIEN-MING LEE ,  KENG-JUNG LEE ,  HUNG-CHIH CHEN

IPC: A61K47/54 ,  A61K47/69 ,  C12N15/10 ,  C12N15/115 ,  A61K47/60 ,  A61P9/10

CPC classification number: A61K47/549 ,  A61K47/60 ,  A61K47/6911 ,  A61K47/6929 ,  A61P9/10 ,  C12N15/115 ,  C12N15/1048 ,  C12N2310/16

Abstract: Monocyte-specific nucleic acid aptamers and lipid nanoparticles comprising such for use in drug delivery. Also disclosed herein are use of the aptamer-based lipid nanoparticle drug delivery system for treating heart injury.