公开(公告)号：US12144822B2

公开(公告)日：2024-11-19

申请号：US17043891

申请日：2019-04-02

Applicant: Academia Sinica

Inventor： Jun-An Chen ,  Kuan-Chih Peng ,  Ying-Tsen Tung

IPC: C07H21/02 ,  A61K31/7105 ,  A61K47/46 ,  A61P21/00 ,  A61P25/00 ,  C12N15/113

Abstract: The present disclosure relates to mir-17˜92 as a candidate therapeutic or diagnostic target of motor neuron (MN) degeneration diseases. Expression of mir-17˜92 is sustained throughout adulthood in spinal MNs and specifically decreases before the onset of MN loss in SOD1G93A mice. Accordingly, mir-17˜92 can be used as a candidate therapeutic target for ALS.