公开(公告)号：US11246883B2

公开(公告)日：2022-02-15

申请号：US16337583

申请日：2017-09-29

Applicant: Academia Sinica

Inventor： Patrick C. H. Hsieh ,  Chen-Yun Chen ,  Yu-Che Cheng

IPC: A61K31/7105 ,  A61K9/00 ,  C07K16/28 ,  C12N15/113 ,  A61K48/00 ,  A61K39/00

Abstract: Methods for ameliorating cardiac is juries such as myocardial infarction by either enhancing the activity of a let-7 microRNA or inhibiting the activity of transformation growth factor beta receptor III (T GFBR3). Also provided herein are assay methods for detecting the level of TGFBR3, the level of a let-7 microRNA, or both in a biological sample.

公开(公告)号：US20190275070A1

公开(公告)日：2019-09-12

申请号：US16337583

申请日：2017-09-29

Applicant: Academia Sinica

Inventor： Patrick C.H. Hsieh ,  Chen-Yun Chen ,  Yu-Che Cheng

IPC: A61K31/7105 ,  C07K16/28 ,  C12N15/113 ,  A61K9/00

Abstract: Methods for ameliorating cardiac is juries such as myocardial infarction by either enhancing the activity of a let-7 microRNA or inhibiting the activity of transformation growth factor beta receptor III (T GFBR3). Also provided herein are assay methods for detecting the level of TGFBR3, the level of a let-7 microRNA, or both in a biological sample.