公开(公告)号：US20180369249A1

公开(公告)日：2018-12-27

申请号：US16075202

申请日：2017-02-03

申请人： Academia Sinica ,  National Taiwan University

发明人： Chi-Huey Wong ,  Pan-Chyr Yang ,  Jim-Min Fang ,  Szu-Hua Pan ,  Ting-Jen R. Cheng ,  Ling-Wei Li

IPC分类号： A61K31/522 ,  A61K35/00

摘要： The present disclosure provides compounds of Formulas (I′) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.

公开(公告)号：US10765681B2

公开(公告)日：2020-09-08

申请号：US16075202

申请日：2017-02-03

申请人： Academia Sinica ,  National Taiwan University

发明人： Chi-Huey Wong ,  Pan-Chyr Yang ,  Jim-Min Fang ,  Szu-Hua Pan ,  Ting-Jen R. Cheng ,  Ling-Wei Li

IPC分类号： C07D473/00 ,  A61K31/522 ,  A61K45/06 ,  A61K31/337 ,  A61K31/52 ,  A61K31/506 ,  A61K31/502 ,  A61K31/167 ,  A61K31/454 ,  A61K38/05 ,  A61K31/517 ,  A61K31/4025 ,  A61K31/5377 ,  A61K31/69 ,  A61K31/44 ,  A61K35/00

摘要： The present disclosure provides compounds of Formulas (I′) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.