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    SINGLE-ARM ACTRIIA AND ACTRIIB HETEROMULTIMERS AND METHODS FOR TREATING PULMONARY HYPERTENSION
    2.
    发明公开
    SINGLE-ARM ACTRIIA AND ACTRIIB HETEROMULTIMERS AND METHODS FOR TREATING PULMONARY HYPERTENSION 审中-公开

    公开(公告)号：US20230190875A1

    公开(公告)日：2023-06-22

    申请号：US17784029

    申请日：2020-12-09

    Applicant: Acceleron Pharma Inc.

    Inventor： Ravindra Kumar ,  Gang Li

    IPC: A61K38/17 ,  A61P9/12 ,  A61K45/06

    CPC classification number: A61K38/179 ,  A61K38/1796 ,  A61K45/06 ,  A61P9/12

    Abstract: In some aspects, the disclosure relates to single-arm ActRIIA heteromultimers and single-arm ActRIIB heteromultimers and methods of using such heteromultimers to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications. The disclosure also provides methods of using a single-arm ActRIIA heteromultimer or single-arm ActRIIB heteromultimer to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. The disclosure further provides methods of using single-arm ActRIIA heteromultimers and single-arm ActRIIB heteromultimers to reduce right ventricular systolic pressure in a subject in need thereof.

    ACTRII PROTEINS AND USES THEREOF
    5.
    发明公开
    ACTRII PROTEINS AND USES THEREOF 审中-公开

    公开(公告)号：US20240277806A1

    公开(公告)日：2024-08-22

    申请号：US18568112

    申请日：2022-06-10

    Applicant: Acceleron Pharma Inc.

    Inventor： Gang Li ,  Patrick Andre ,  Ravindra Kumar

    IPC: A61K38/17 ,  A61P9/12

    CPC classification number: A61K38/179 ,  A61P9/12

    Abstract: In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension associated with lung disease (e.g, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)), particularly treating, preventing or reducing the progression rate and/or severity of one or more pulmonary hypertension associated with lung disease (e.g., pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)) associated complications.

    SINGLE-ARM ACTRIIA AND ACTRIIB HETEROMULTIMERS AND METHODS FOR TREATING RENAL DISEASES OR CONDITIONS
    8.
    发明申请
    SINGLE-ARM ACTRIIA AND ACTRIIB HETEROMULTIMERS AND METHODS FOR TREATING RENAL DISEASES OR CONDITIONS 有权

    公开(公告)号：US20230134083A1

    公开(公告)日：2023-05-04

    申请号：US17911347

    申请日：2021-03-11

    Applicant: Acceleron Pharma Inc.

    Inventor： Gang Li ,  Ravindra Kumar

    IPC: C07K19/00 ,  A61K38/13 ,  A61K38/17 ,  A61K47/68 ,  C07K14/71

    Abstract: In some aspects, the disclosure relates to single-arm AetRIIA heteromultimers and sing-arm ActRIIB heteromultimers and methods of using such heteromultimers to treat, prevent, or reduce tire progression rate and/or severity of renal diseases or conditions, particularly treating, preventing or reducing the progression rate and/or severity of one or more renal-associated complications. The disclosure also provides methods of using a single-arm ActRIIA heteromultimer or single-arm ActRIIB heteromultimer to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, Alport syndrome, focal segmental glomerulosclerosis (FSGS), polycystic kidney disease, and/or chronic kidney disease.

    COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE 审中-公开

    公开(公告)号：US20200087367A1

    公开(公告)日：2020-03-19

    申请号：US16482883

    申请日：2018-02-05

    Applicant: Acceleron Pharma Inc.

    Inventor： Gang Li ,  Asya Grinberg ,  Dianne Sako

    IPC: C07K14/51 ,  C07K14/71 ,  C07K14/705 ,  C07K16/22 ,  A61P9/04

    Abstract: In certain aspects, the present disclosure relates to methods of treating, preventing, and reducing the severity or progression of heart failure or one or more complications of heart failure. For example, the disclosure provides various BMP antagonists, such as ActRIIA polypeptides, ActRIIB polypeptides, BMPRII polypeptides, ALKI polypeptides, endoglin polypeptides, BMP 10 propeptide proteins and Fc fusion proteins thereof as well as anti-BMP9 antibodies, for treating, preventing and reducing the severity or progression of heart failure or one or more complications of heart failure.

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