公开(公告)号：US20220372107A1

公开(公告)日：2022-11-24

申请号：US17052785

申请日：2019-05-02

Applicant: Acceleron Pharma Inc.

Inventor： Ravindra Kumar ,  Dianne S. Sako ,  Roselyne Castonguay ,  Tzu-Hsing Kuo

IPC: C07K14/705 ,  C07K14/71 ,  C07K16/22

Abstract: In certain aspects, the disclosure provides multispecific binders (e.g., ActRIIA:TβRII heteromultimers comprising an ActRIIA polypeptide and a TfiRU polypeptide). The disclosure further provides that such multispecific binders (e.g., ActRIIA:TβRII heteromultimer) may be used to treat various disorders or conditions.

公开(公告)号：US12168683B2

公开(公告)日：2024-12-17

申请号：US17052783

申请日：2019-05-02

Applicant: Acceleron Pharma Inc.

Inventor： Ravindra Kumar ,  Dianne S. Sako ,  Roselyne Castonguay ,  Tzu-Hsing Kuo

IPC: C07K14/71 ,  A61K38/00 ,  C07K14/47 ,  C07K16/22

Abstract: In certain aspects, the disclosure provides multispecific binders (e.g., ActRIIB:TβRII heteromultimers comprising an ActRIIB polypeptide and a TβRII polypeptide). In some embodiments, the disclosure provides for novel binders comprising a TβRII polypeptide and a heterologous portion. The disclosure further provides that such multispecific binders (e.g., ActRIIB:TβRII heteromultimer) may be used to treat various disorders or conditions.

公开(公告)号：US12103959B2

公开(公告)日：2024-10-01

申请号：US17052785

申请日：2019-05-02

Applicant: Acceleron Pharma Inc.

Inventor： Ravindra Kumar ,  Dianne S. Sako ,  Roselyne Castonguay ,  Tzu-Hsing Kuo

IPC: C07K14/705 ,  A61K38/00 ,  C07K14/71 ,  C07K16/22

CPC classification number: C07K14/70578 ,  C07K14/71 ,  C07K16/22 ,  A61K38/00 ,  C07K2319/02 ,  C07K2319/30

Abstract: In certain aspects, the disclosure provides multispecific binders (e.g., ActRIIA:TβRII heteromultimers comprising an ActRIIA polypeptide and a TβRII polypeptide). The disclosure further provides that such multispecific binders (e.g., ActRIIA:TβRII heteromultimer) may be used to treat various disorders or conditions.

公开(公告)号：US20210380663A1

公开(公告)日：2021-12-09

申请号：US17052783

申请日：2019-05-02

Applicant: Acceleron Pharma Inc.

Inventor： Ravindra Kumar ,  Dianne S. Sako ,  Roselyne Castonguay ,  Tzu-Hsing Kuo

IPC: C07K14/71 ,  C07K14/47 ,  C07K16/22

Abstract: In certain aspects, the disclosure provides multispecific binders (e.g., ActRIIB:TβRII heteromultimers comprising an ActRIIB polypeptide and a TβMII polypeptide). In some embodiments, the disclosure provides for novel binders comprising a TβRII polypeptide and a heterologous portion. The disclosure further provides that such multispecific binders (e.g., ActRII:TβRII heteromultimer) may be used to treat various disorders or conditions.