公开(公告)号：US11701409B2

公开(公告)日：2023-07-18

申请号：US16074330

申请日：2017-02-01

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： A61K38/22 ,  A61K47/54 ,  A61K31/704 ,  A61P9/04 ,  A61P9/12

CPC分类号： A61K38/22 ,  A61K31/704 ,  A61K47/542 ,  A61P9/04 ,  A61P9/12

摘要： Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo. The agonists are delivered to an individual at a dose sufficient to reduce hypertension and ischemic injury, and to reduce cardiotoxicity associated with chemotherapeutic agents.

公开(公告)号：US20220340633A1

公开(公告)日：2022-10-27

申请号：US17316153

申请日：2021-05-10

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  C07K19/00 ,  C07K16/26

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist or superantagonist activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific.

公开(公告)号：US20220324935A1

公开(公告)日：2022-10-13

申请号：US17837736

申请日：2022-06-10

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  C07K14/585 ,  A61K47/60 ,  A61K47/54 ,  A61K45/06 ,  C07K14/47 ,  C07K14/655

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist, super-antagonist, or multiple receptor modulatng activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific for multiple G protein-coupled receptors.

公开(公告)号：US20210000922A1

公开(公告)日：2021-01-07

申请号：US16074330

申请日：2017-02-01

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： A61K38/22 ,  A61K47/54 ,  A61K31/704 ,  A61P9/04 ,  A61P9/12

摘要： Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo. The agonists are delivered to an individual at a dose sufficient to reduce hypertension and ischemic injury, and to reduce cardiotoxicity associated with chemotherapeutic agents.

公开(公告)号：US12110318B2

公开(公告)日：2024-10-08

申请号：US17837736

申请日：2022-06-10

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  A61K38/00 ,  A61K45/06 ,  A61K47/54 ,  A61K47/60 ,  C07K14/47 ,  C07K14/585 ,  C07K14/655 ,  A61K9/00

CPC分类号： C07K14/575 ,  A61K45/06 ,  A61K47/542 ,  A61K47/60 ,  C07K14/47 ,  C07K14/57527 ,  C07K14/585 ,  C07K14/655 ,  A61K9/0019 ,  A61K38/00 ,  C07K2319/00

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist, super-antagonist, or multiple receptor modulating activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific for multiple G protein-coupled receptors.

公开(公告)号：US11034745B2

公开(公告)日：2021-06-15

申请号：US16066609

申请日：2017-01-04

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  C07K19/00 ,  C07K16/26 ,  A61K38/00

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist or superantagonist activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific.

公开(公告)号：US20200339649A1

公开(公告)日：2020-10-29

申请号：US16922850

申请日：2020-07-07

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  C07K14/585 ,  A61K47/60 ,  A61K47/54 ,  A61K45/06 ,  C07K14/47 ,  C07K14/655

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist, super-antagonist, or multiple receptor modulatng activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific for multiple G protein-coupled receptors.

公开(公告)号：US20190153059A1

公开(公告)日：2019-05-23

申请号：US16016235

申请日：2018-06-22

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  A61K47/60 ,  C07K14/585

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist, super-antagonist, or multiple receptor modulatng activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific for multiple G protein-coupled receptors.

公开(公告)号：US20190010203A1

公开(公告)日：2019-01-10

申请号：US16066609

申请日：2017-01-04

申请人： Adepthera LLC

发明人： Sheau Yu Teddy Hsu

IPC分类号： C07K14/575 ,  C07K16/26

摘要： Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist or superantagonist activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific.