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公开(公告)号：US5807569A
公开(公告)日：1998-09-15
申请号：US443041
申请日：1995-05-17
CPC分类号： A61K9/08 , A61K9/06 , Y10S514/944
摘要： Two-component pharmaceutical compositions for topical application to the human or animal body and intended for mixing together on or immediately prior to application, comprising two liquid phases having different lipophilicities and a drug dissolved in at least one of the liquid phases.
摘要翻译： 用于局部施用于人或动物体并且用于在施用之后或紧接着施用之前混合的双组分药物组合物，其包含两种具有不同亲脂性的液相和溶解在至少一种液相中的药物。
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公开(公告)号：US08541470B2
公开(公告)日：2013-09-24
申请号：US12530960
申请日：2008-02-15
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
IPC分类号： A61K31/196 , A61P29/00
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/196 , A61K47/10 , A61K47/14
摘要： A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSAID may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.
摘要翻译： 用于局部施用NSAID的组合物包含NSAID在包含多元醇，二醇醚和高级脂肪酸的酯的载体系统中的溶液或悬浮液，所述载体系统在环境温度下以单相存在。 NSAID可以是双氯芬酸作为双氯芬酸。 多元醇可以是二醇如异丙二醇，二醇醚可以是二甘醇醚如二甘醇单乙醚。
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公开(公告)号：US20120248142A1
公开(公告)日：2012-10-04
申请号：US13497920
申请日：2010-11-10
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
IPC分类号： A61K31/245 , B67D7/16 , A61P15/00 , A61K31/167 , A61P23/02
CPC分类号： A61K31/245 , A61K9/0014 , A61K9/0034 , A61K47/02 , A61K47/24 , A61K47/34
摘要： A pharmaceutical composition comprises an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity.
摘要翻译： 药物组合物包含溶解在包含挥发性和非挥发性组分的基本上非水性载体体系中的活性成分，其中挥发性组分包含用于活性成分的挥发性非溶剂和用于非溶剂的挥发性溶剂化添加剂和 非挥发性组分包含非挥发性非溶剂和任选的活性成分的非挥发性溶剂，挥发性和非挥发性非溶剂包含分别具有不同粘度的硅氧烷流体。
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公开(公告)号：US20100099767A1
公开(公告)日：2010-04-22
申请号：US12530960
申请日：2008-02-15
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
IPC分类号： A61K31/196 , A61P29/00
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/196 , A61K47/10 , A61K47/14
摘要： A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSAID may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.
摘要翻译： 用于局部施用NSAID的组合物包含NSAID在包含多元醇，二醇醚和高级脂肪酸的酯的载体系统中的溶液或悬浮液，所述载体系统在环境温度下以单相存在。 NSAID可以是双氯芬酸作为双氯芬酸。 多元醇可以是二醇如异丙二醇，二醇醚可以是二甘醇醚如二甘醇单乙醚。
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公开(公告)号：US20090018214A1
公开(公告)日：2009-01-15
申请号：US12223583
申请日：2007-01-23
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
CPC分类号： A61K9/0014 , A61K9/0034 , A61K9/145 , A61K31/21 , A61K45/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a “virtual injection” of the active ingredient to be delivered transdermally without general systemic uptake.
摘要翻译： 用于局部施用于身体一部分的组合物包括局部麻醉剂和任选的血管扩张剂作为活性成分溶解在活性成分的不同溶剂化能力的挥发性和非挥发性溶剂的混合物中。 血管扩张剂可以包括硝酸三甘油酯，局部麻醉剂可以包含氨基酰胺或氨基酸类型的麻醉剂。 挥发性溶剂可以包括水与C1-C5醇的混合物，并且非挥发性溶剂可以包含多元醇和任选的二醇。 还描述了含低浓度血管扩张剂的组合物。 组合物允许活性成分的“虚拟注射”经皮递送而不需要全身吸收。
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公开(公告)号：US09358219B2
公开(公告)日：2016-06-07
申请号：US13497920
申请日：2010-11-10
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
CPC分类号： A61K31/245 , A61K9/0014 , A61K9/0034 , A61K47/02 , A61K47/24 , A61K47/34
摘要： A pharmaceutical composition comprises an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity.
摘要翻译： 药物组合物包含溶解在包含挥发性和非挥发性成分的基本上非水性载体体系中的活性成分，其中挥发性组分包含用于活性成分的挥发性非溶剂和用于非溶剂的挥发性溶剂化添加剂和 非挥发性组分包含非挥发性非溶剂和任选的活性成分的非挥发性溶剂，挥发性和非挥发性非溶剂包含分别具有不同粘度的硅氧烷流体。
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公开(公告)号：US5673821A
公开(公告)日：1997-10-07
申请号：US438222
申请日：1995-05-09
CPC分类号： B05B11/3085 , B05B11/0048 , B05B11/3074 , B05B11/3001
摘要： A dispenser is provided for the concurrent dispensing of two different fluid materials. The dispenser has a first and second supply chamber for containing the two separate fluids, and a headpiece having a first pump chamber and pump piston connected to the first supply chamber and a first discharge channel, and a second pump chamber and pump piston connected to the second supply chamber and a second discharge channel. The first and second supply chambers have a coaxial arrangement.
摘要翻译： 提供了用于同时分配两种不同流体材料的分配器。 分配器具有用于容纳两个分开的流体的第一和第二供应室，以及连接到第一供应室的第一泵室和泵活塞的头盔和第一排放通道，以及连接到第一供应室的第二泵室和泵活塞 第二供应室和第二排放通道。 第一和第二供应室具有同轴布置。
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公开(公告)号：US08951553B2
公开(公告)日：2015-02-10
申请号：US11659815
申请日：2005-08-08
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/21 , A61K47/10 , Y10S514/944
摘要： A composition for topical application to a part of the body comprises a vasodilator, for example glyceryl trinitrate, as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the vasodilator. The vasoldator is present in the composition at a concentration at or slightly below saturation, whereby evaporation of the volatile solvent in use will maintain the vasodilator at saturated or super-saturated concentrations in the residue, whereby the vasodilator will become saturated or supersaturated in the solvent remaining and, as the active ingredient passes through the skin and is absorbed in the bloodstream, and thus becomes depleted in the residual composition, continuing evaporation of volatile solvent will maintain the active ingredient substantially at saturation or supersaturation level in the residual composition throughout the major part of the absorption phase, thereby maximising absorption levels but at a moderate dosage level.
摘要翻译： 用于局部施用于身体的一部分的组合物包含血管扩张剂，例如三水硝酸甘油酯，作为溶解在用于血管扩张剂的不同溶剂化能力的挥发性和非挥发性溶剂的共混物中的活性成分。 挥发物以组合物浓度存在于或稍低于饱和度，由此在使用中挥发性溶剂的蒸发将使血管扩张剂在残留物中保持饱和或超饱和浓度，由此血管扩张剂将在溶剂中变得饱和或过饱和 剩余的，并且由于活性成分通过皮肤并被吸收在血液中，并且因此变得耗尽残留组合物，挥发性溶剂的持续蒸发将使整个主要的残留组合物中的活性成分基本维持在饱和或过饱和水平 吸收阶段的一部分，从而使吸收水平最大化，但处于适度的剂量水平。
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公开(公告)号：US20080081058A1
公开(公告)日：2008-04-03
申请号：US11659815
申请日：2005-08-08
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/21 , A61K47/10 , Y10S514/944
摘要： A composition for topical application to a part of the body comprises a vasodilator, for example glyceryl trinitrate, as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the vasodilator. The vasoldator is present in the composition at a concentration at or slightly below saturation, whereby evaporation of the volatile solvent in use will maintain the vasodilator at saturated or super-saturated concentrations in the residue, whereby the vasodilator will become saturated or supersaturated in the solvent remaining and, as the active ingredient passes through the skin and is absorbed in the bloodstream, and thus becomes depleted in the residual composition, continuing evaporation of volatile solvent will maintain the active ingredient substantially at saturation or supersaturation level in the residual composition throughout the major part of the absorption phase, thereby maximising absorption levels but at a moderate dosage level.
摘要翻译： 用于局部施用于身体的一部分的组合物包含血管扩张剂，例如三水硝酸甘油酯，作为溶解在用于血管扩张剂的不同溶剂化能力的挥发性和非挥发性溶剂的共混物中的活性成分。 挥发物以组合物浓度存在于或稍低于饱和度，由此在使用中挥发性溶剂的蒸发将使血管扩张剂在残留物中保持饱和或超饱和浓度，由此血管扩张剂将在溶剂中变得饱和或过饱和 剩余的，并且由于活性成分通过皮肤并被吸收在血液中，并且因此变得耗尽残留组合物，挥发性溶剂的持续蒸发将使整个主要的残留组合物中的活性成分基本维持在饱和或过饱和水平 吸收阶段的一部分，从而使吸收水平最大化，但处于适度的剂量水平。
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公开(公告)号：US09265721B2
公开(公告)日：2016-02-23
申请号：US12223583
申请日：2007-01-23
申请人： Adrian Francis Davis
发明人： Adrian Francis Davis
CPC分类号： A61K9/0014 , A61K9/0034 , A61K9/145 , A61K31/21 , A61K45/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a “virtual injection” of the active ingredient to be delivered transdermally without general systemic uptake.
摘要翻译： 用于局部施用于身体一部分的组合物包括局部麻醉剂和任选的血管扩张剂作为活性成分溶解在活性成分的不同溶剂化能力的挥发性和非挥发性溶剂的混合物中。 血管扩张剂可以包括硝酸三甘油酯，局部麻醉剂可以包含氨基酰胺或氨基酸类型的麻醉剂。 挥发性溶剂可以包括水与C1-C5醇的混合物，并且非挥发性溶剂可以包含多元醇和任选的二醇。 还描述了含低浓度血管扩张剂的组合物。 组合物允许活性成分的“虚拟注射”经皮递送而不需要全身吸收。
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