公开(公告)号：US20070208015A1

公开(公告)日：2007-09-06

申请号：US10599931

申请日：2005-04-13

申请人： Adrian Gill ,  Maria Carr ,  John Lyons ,  Neil Thompson ,  David Rees

发明人： Adrian Gill ,  Maria Carr ,  John Lyons ,  Neil Thompson ,  David Rees

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07D333/36 ,  C07D409/12 ,  C07D417/12

摘要： The invention provides compounds of the formula (I) or a salt, solvate or N-oxide thereof, wherein: R1 and R2 are the same or different and each is selected from hydrogen, saturated C1-3 hydrocarbyl, halogen and cyano; X is selected from C═O, C═S, C(═O)NH, C(═S)NH, C(═O)O, C(═O)S, C(═S)O and C(═S)S; R3 is selected from aryl and heteroaryl groups each having from 5 to 12 ring members and being unsubstituted or substituted by one or more substituent groups R10 as defined in the claims; R4 and R5 are the same or different and are selected from hydrogen and methyl; or one of R4 and R5 is selected from hydroxymethyl and ethyl and the other is hydrogen; and R6 and R7 are the same or different and are selected from hydrogen and methyl. The compounds of the formula (I) hayed activity as p38 MAP kinase and Taf kinase inhibitors.

摘要翻译： 本发明提供式（I）化合物或其盐，溶剂合物或N-氧化物，其中：R 1和R 2相同或不同，各自为 选自氢，饱和C 1-3烃基，卤素和氰基; X选自C-O，C-S，C（-O）NH，C（-S）NH，C（-O）O，C（-O）S，C（-S）O和C（-S） R 3选自具有5至12个环成员的芳基和杂芳基，并且未被取代或被权利要求中所定义的一个或多个取代基R 10取代; R 4和R 5相同或不同，并且选自氢和甲基; 或者R 4和R 5中的一个选自羟甲基和乙基，另一个是氢; 和R 6和R 7相同或不同，并且选自氢和甲基。 式（I）化合物具有作为p38 MAP激酶和Taf激酶抑制剂的活性。

公开(公告)号：US06247149B1

公开(公告)日：2001-06-12

申请号：US08959429

申请日：1997-10-28

申请人： Patrick Terence Falls ,  Neil Thompson

发明人： Patrick Terence Falls ,  Neil Thompson

IPC分类号： G06F1100

CPC分类号： G06F11/0781 ,  G06F11/0748

摘要： A distributed logging system for maintaining and retrieving diagnostic logging information in an efficient manner. A local cache of logging information is maintained at an analysis computer and the local cache is first examined to determine if diagnostic information exists in the cache or if it must be retrieved from a remote server. If the requested diagnostic information is available in the local cache, the local cache is accessed to retrieve the information. If any portion of the requested diagnostic information is not available in the local cache, the information is located and read from the appropriate log file(s) on the remote server, and then stored in the local cache so that subsequent requests for that diagnostic information will not necessitate accessing the remote computer. Native I/O functions are used to allow access to the diagnostic information regardless of the status of the distributed system.

摘要翻译： 分布式记录系统，用于以有效的方式维护和检索诊断记录信息。 在分析计算机上维护日志记录信息的本地缓存，并且首先检查本地缓存以确定诊断信息是否存在于缓存中，或者是否必须从远程服务器检索。 如果请求的诊断信息在本地缓存中可用，则访问本地缓存以检索信息。 如果请求的诊断信息的任何部分在本地缓存中不可用，则该信息位于远程服务器上的相应日志文件中并从其读取，然后存储在本地缓存中，以便对该诊断信息的后续请求 不需要访问远程计算机。 本地I / O功能用于允许访问诊断信息，而不管分布式系统的状态如何。