公开(公告)号：US20130266619A1

公开(公告)日：2013-10-10

申请号：US13911547

申请日：2013-06-06

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed F.A. Hossainy

IPC: A61L31/16

CPC classification number: A61L31/16 ,  A61K31/445 ,  A61K31/74 ,  A61L31/10 ,  C08L33/06

Abstract: A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed.

Abstract translation: 公开了包含包含线型丙烯酸均聚物或线性丙烯酸共聚物的结构组分和包含具有丙烯酸酯部分和生物有益部分的共聚物的生物有益成分的组合物。 还公开了包含其涂层中的组合物的医疗制品和制造医疗制品的方法。

公开(公告)号：US20130253468A1

公开(公告)日：2013-09-26

申请号：US13896173

申请日：2013-05-16

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed F.A. Hossainy

IPC: A61L27/54 ,  A61L27/34

CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/416 ,  A61L2300/606 ,  C08L89/06 ,  C08L89/00

Abstract: A stent with a coating including a composition that releases a therapeutic substance in response to an enzyme is disclosed. The composition includes a polymer or polypeptide that includes an amino acid sequence which is recognized and cleaved by at least one of the matrix metalloproteinases (MMP).

Abstract translation: 公开了具有涂层的支架，其包含响应于酶释放治疗物质的组合物。 该组合物包括聚合物或多肽，其包含由至少一种基质金属蛋白酶（MMP）识别和切割的氨基酸序列。