公开(公告)号：US09173982B2

公开(公告)日：2015-11-03

申请号：US13734860

申请日：2013-01-04

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Stephen Dirk Pacetti

IPC: A61F13/00 ,  A61F2/00 ,  A61L31/10 ,  A61L27/16 ,  A61L27/54 ,  A61L31/16 ,  C09D129/04 ,  C09D129/06 ,  A61L27/30

CPC classification number: A61L31/10 ,  A61L27/16 ,  A61L27/30 ,  A61L27/54 ,  A61L31/16 ,  C09D129/04 ,  C09D129/06 ,  C08L29/02

Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

公开(公告)号：US08758801B2

公开(公告)日：2014-06-24

申请号：US13686392

申请日：2012-11-27

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Stephen Dirk Pacetti ,  Thierry Glauser

IPC: A61F2/00 ,  C08G63/00 ,  C08G63/08 ,  C08G63/91 ,  C08G67/00 ,  C08G69/00 ,  C08L67/00

CPC classification number: A61L31/10 ,  A61L27/34 ,  C08G63/66 ,  C09D167/00

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。

公开(公告)号：US20140060425A1

公开(公告)日：2014-03-06

申请号：US14076022

申请日：2013-11-08

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Andrew J. Tochterman ,  William J. Fox ,  Nathan Harold

IPC: A61F2/82

CPC classification number: A61F2/82 ,  B05B13/02 ,  B05B13/0627 ,  B05B13/0636 ,  B05B13/0654 ,  B05D1/32 ,  B05D7/22 ,  B05D2258/02 ,  Y10T29/53678 ,  Y10T29/53683 ,  Y10T29/53909

Abstract: With abluminal side of a stent masked, the luminal side of the stent is selectively coated with a substance, such as an anti-coagulant, a platelet inhibitor and/or a pro-healing substance. The stent can be masked by inserting it into a rigid mandrel chamber or by compressing a masking sleeve onto the outer side of the stent. A spray nozzle inserted into the masked stent spray coats the substance onto the luminal side. The sprayed coating can be cured onto the stent such as by inserting an electrical-resistance heater bar into the stent.

Abstract translation: 随着支架的外侧面被遮盖，支架的腔侧选择性地涂覆有诸如抗凝血剂，血小板抑制剂和/或前维持物质的物质。 可以通过将支架插入刚性心轴腔室中或通过将掩蔽套管压缩到支架的外侧来掩蔽支架。 插入掩模的支架喷雾器中的喷嘴将物质涂覆在腔侧。 喷涂的涂层可以固化到支架上，例如通过将电阻加热棒插入支架中。

公开(公告)号：US20130325100A1

公开(公告)日：2013-12-05

申请号：US13963333

申请日：2013-08-09

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Wouter Roorda ,  Tim A. Limon ,  Stephen D. Pacetti

IPC: A61F2/958

CPC classification number: A61F2/958 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

Abstract: A stent delivery catheter system having a catheter with stent releasably mounted on a stent retention portion of the catheter for delivery and deployment within a patient's body lumen, and a method of mounting the stent on the stent retention portion of the catheter. The method generally includes exposing the stent retention portion and/or the stent to a solvent, the solvent being in the vapor phase. The vapor phase solvent typically softens the stent retention portion of the catheter, and/or, in one embodiment in which the stent has a coating on the stent body, the vapor phase solvent softens the stent coating. In a presently preferred embodiment, the stent polymeric coating has a therapeutic agent, and the method of the invention prevents or inhibits disadvantageously affecting the therapeutic agent coating during mounting of the stent on the catheter.

Abstract translation: 一种具有导管的支架输送导管系统，其具有可释放地安装在导管的支架保持部分上的支架，用于在患者的体腔内输送和展开，以及将支架安装在导管的支架保持部分上的方法。 该方法通常包括将支架保持部分和/或支架暴露于溶剂中，溶剂处于气相。 气相溶剂通常软化导管的支架保留部分，和/或在其中支架在支架主体上具有涂层的一个实施例中，气相溶剂软化支架涂层。 在目前优选的实施方案中，支架聚合物涂层具有治疗剂，并且本发明的方法在将支架安装在导管上时防止或抑制不利地影响治疗剂涂层。

公开(公告)号：US20130253468A1

公开(公告)日：2013-09-26

申请号：US13896173

申请日：2013-05-16

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed F.A. Hossainy

IPC: A61L27/54 ,  A61L27/34

CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/416 ,  A61L2300/606 ,  C08L89/06 ,  C08L89/00

Abstract: A stent with a coating including a composition that releases a therapeutic substance in response to an enzyme is disclosed. The composition includes a polymer or polypeptide that includes an amino acid sequence which is recognized and cleaved by at least one of the matrix metalloproteinases (MMP).

Abstract translation: 公开了具有涂层的支架，其包含响应于酶释放治疗物质的组合物。 该组合物包括聚合物或多肽，其包含由至少一种基质金属蛋白酶（MMP）识别和切割的氨基酸序列。

公开(公告)号：US20130149430A1

公开(公告)日：2013-06-13

申请号：US13720667

申请日：2012-12-19

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC

Inventor： Syed Faiyaz Ahmed Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

IPC: B05D5/00

CPC classification number: B05D5/00 ,  A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/02

Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

Abstract translation: 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。

公开(公告)号：US08439966B1

公开(公告)日：2013-05-14

申请号：US13728431

申请日：2012-12-27

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Timothy Limon

IPC: A61F2/06

CPC classification number: A61F2/06 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/828 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054

Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.

公开(公告)号：US20130116769A1

公开(公告)日：2013-05-09

申请号：US13728431

申请日：2012-12-27

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.

Inventor： Timothy Limon

IPC: A61F2/90

CPC classification number: A61F2/06 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/828 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054

Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.

公开(公告)号：US20130048872A1

公开(公告)日：2013-02-28

申请号：US13662214

申请日：2012-10-26

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC

Inventor： Bin HUANG ,  Abigail FREEMAN ,  Daniel CASTRO ,  David C. GALE

IPC: A61L2/08

CPC classification number: A61L2/08 ,  A61L2/081 ,  A61L2/082 ,  A61L2/085 ,  A61L2/087 ,  A61L2/10 ,  A61L2202/23 ,  A61L2202/24 ,  B65B55/00 ,  B65B55/16

Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.

Abstract translation: 公开了用于降低放射线灭菌的支架的方法和系统。

公开(公告)号：US20030055449A1

公开(公告)日：2003-03-20

申请号：US09957354

申请日：2001-09-19

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White ,  Jose A. Romero

IPC: A61M029/00

CPC classification number: A61F2/95 ,  A61B2090/3954 ,  A61L29/106 ,  A61L29/126 ,  A61L29/18 ,  A61M25/10 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1079

Abstract: Medical devices or components thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, which are formed at least in part of a polymeric material and a ferromagnetic or paramagnetic material, so that the medical device or component thereof is visible on magnetic resonance imaging (MRI) scans. In one embodiment, the medical device is a balloon catheter having an MRI visible balloon. In a presently preferred embodiment, there is an insufficient amount of the ferromagnetic or paramagnetic material within a wall of the balloon or coated onto a wall of the balloon to make the balloon radiopaque.

Abstract translation: 医疗器械或其组件，特别是用于治疗或诊断用途的体内器件，其至少部分地由聚合物材料和铁磁性或顺磁性材料形成，使得医疗器械或其组件在磁共振成像（MRI） ）扫描。 在一个实施例中，医疗装置是具有MRI可见气囊的气囊导管。 在目前优选的实施方案中，在球囊的壁内存在不足量的铁磁性或顺磁性材料，或涂覆在气球的壁上，以使气球不透射线。