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公开(公告)号:US20150232808A1
公开(公告)日:2015-08-20
申请号:US14525378
申请日:2014-10-28
IPC分类号: C12N5/0735 , C12Q1/68
CPC分类号: C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译: 本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法,以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。 更具体地说,本发明涉及用于鉴定,扩增培养和配制哺乳动物多能干细胞和分化细胞的方法,所述哺乳动物多能干细胞和分化细胞在成年人的细胞基因表达模式中不同,因此提供独特的特征,其提供新颖的治疗策略 退行性疾病的治疗。
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公开(公告)号:US20170152475A9
公开(公告)日:2017-06-01
申请号:US14525378
申请日:2014-10-28
IPC分类号: C12N5/0735 , C12Q1/68
CPC分类号: C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
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