公开(公告)号：US20190225937A1

公开(公告)日：2019-07-25

申请号：US16102640

申请日：2018-08-13

申请人： Advanced Cell Technology, Inc.

发明人： Michael D. West

IPC分类号： C12N5/0735 ,  C12N15/85

摘要： Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by de-differentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.

公开(公告)号：US20160369237A1

公开(公告)日：2016-12-22

申请号：US15247786

申请日：2016-08-25

申请人： Advanced Cell Technology, Inc.

发明人： Michael D. West ,  Geoffrey Sargent ,  James Teruo Murai ,  Steven Kessler ,  Karen Chapman

IPC分类号： C12N5/0775 ,  C12N5/071 ,  A61K35/407 ,  A61K35/30 ,  A61K35/39 ,  C12N5/0793 ,  A61K35/34

CPC分类号： C12N5/0662 ,  A61K35/30 ,  A61K35/34 ,  A61K35/39 ,  A61K35/407 ,  C12N5/0606 ,  C12N5/0619 ,  C12N5/0652 ,  C12N5/0657 ,  C12N5/067 ,  C12N5/0676 ,  C12N2506/02

摘要： This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.

摘要翻译： 本发明一般涉及区分多能干细胞（例如胚胎干，胚胎胚芽或胚源性细胞）的方法，以从细胞的不均匀混合物获得细胞亚群，其中与原始多能性相比，细胞亚群具有降低的分化潜能 干细胞和亚群能够传播的地方。

公开(公告)号：US20150232808A1

公开(公告)日：2015-08-20

申请号：US14525378

申请日：2014-10-28

申请人： Advanced Cell Technology, Inc.

发明人： Michael D. West ,  Karen B. Chapman ,  Roy Geoffrey Sargent

IPC分类号： C12N5/0735 ,  C12Q1/68

CPC分类号： C12N5/0606 ,  A01K67/0271 ,  C12N5/0676 ,  C12N5/16 ,  C12N15/873 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/72 ,  C12N2506/00 ,  C12N2506/11 ,  C12Q1/6881 ,  C12Q2600/158

摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.

摘要翻译： 本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。 更具体地说，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞的方法，所述哺乳动物多能干细胞和分化细胞在成年人的细胞基因表达模式中不同，因此提供独特的特征，其提供新颖的治疗策略 退行性疾病的治疗。

公开(公告)号：US20170152475A9

公开(公告)日：2017-06-01

申请号：US14525378

申请日：2014-10-28

申请人： Advanced Cell Technology, Inc.

发明人： Michael D. West ,  Karen B. Chapman ,  Roy Geoffrey Sargent

IPC分类号： C12N5/0735 ,  C12Q1/68

CPC分类号： C12N5/0606 ,  A01K67/0271 ,  C12N5/0676 ,  C12N5/16 ,  C12N15/873 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/72 ,  C12N2506/00 ,  C12N2506/11 ,  C12Q1/6881 ,  C12Q2600/158

摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.

公开(公告)号：US20170003278A1

公开(公告)日：2017-01-05

申请号：US15142807

申请日：2016-04-29

申请人： Advanced Cell Technology, Inc.

发明人： Michael D. West ,  Raymond L. Page ,  Hans Schoeler ,  Karen B. Chapman

IPC分类号： G01N33/50 ,  C12Q1/68

CPC分类号： G01N33/5023 ,  C12N5/0652 ,  C12N5/0657 ,  C12N5/069 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/23 ,  C12N2501/998 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2506/04 ,  C12Q1/6888 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5073 ,  G01N33/5091 ,  G01N2333/475 ,  G01N2333/52

摘要： The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.

摘要翻译： 本发明涉及同时或临时地筛选生长因子，粘附分子，免疫刺激分子，细胞外基质组分和其它材料，用于诱导多能干细胞和多能干细胞的定向分化的能力。

公开(公告)号：US20140057348A1

公开(公告)日：2014-02-27

申请号：US14066510

申请日：2013-10-29

申请人： ADVANCED CELL TECHNOLOGY, INC.

发明人： Michael D. West ,  Karen B. Chapman ,  Irina V. Klimanskaya

IPC分类号： C12N5/0735

CPC分类号： C12N5/0606 ,  C12N15/873 ,  C12N2502/04

摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。