公开(公告)号：US20040219134A1

公开(公告)日：2004-11-04

申请号：US10851938

申请日：2004-05-21

申请人： Advanced Tissue Sciences, Inc.

发明人： Gail K. Naughton ,  Jonathan Noel Mansbridge ,  Robert Emmett Pinney ,  Joan Zeltinger

IPC分类号： A01N063/00

CPC分类号： A61L27/3886 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/507

摘要： The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.

摘要翻译： 本发明涉及促进组织器官中血管形成的方法。 特别地，该方法涉及植入或附着工程化的三维基质组织以促进心脏和相关组织中的内皮细胞化和血管发生。 本发明的三维基质组织可用于多种应用，包括但不限于促进损伤的心肌的修复和再生，促进心脏手术期间的血管化和愈合，促进吻合部位的血管形成 并促进损伤的骨骼肌，平滑肌或结缔组织的血管化和修复。