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公开(公告)号：US20210002253A1
公开(公告)日：2021-01-07
申请号：US16936257
申请日：2020-07-22
IPC分类号： C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D217/24 , C07D217/22 , C07D401/04 , C07D405/14 , C07C69/76 , A61P27/06 , C07D401/14 , C07D409/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US11891376B2
公开(公告)日：2024-02-06
申请号：US17895436
申请日：2022-08-25
IPC分类号： C07D401/14 , C07D417/12 , C07D401/12 , A61P27/06 , C07D413/12 , C07D405/12 , C07D417/14
CPC分类号： C07D401/14 , A61P27/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Provided herein are amino isoquinolinyl amide and sulfonamide compounds that affect the function of kinases and other proteins in a cell and that are useful as therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and retinal diseases, as anti-inflammatory agents, for the treatment of cardiovascular diseases, and for diseases characterized by abnormal growth, such as cancers.
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公开(公告)号：US20230130470A1
公开(公告)日：2023-04-27
申请号：US17722832
申请日：2022-04-18
IPC分类号： C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D217/24 , C07D217/22 , C07D401/04 , C07D405/14 , C07C69/76 , A61P27/06 , C07D401/14 , C07D409/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US10858339B2
公开(公告)日：2020-12-08
申请号：US15941993
申请日：2018-03-30
IPC分类号： C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D217/24 , C07D217/22 , C07D401/04 , C07D405/14 , C07C69/76 , A61P27/06 , C07D401/14 , C07D409/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US12018012B2
公开(公告)日：2024-06-25
申请号：US17722832
申请日：2022-04-18
IPC分类号： C07D401/12 , A61P27/06 , C07C69/76 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , A61P27/06 , C07C69/76 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07C2601/02
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US11427563B2
公开(公告)日：2022-08-30
申请号：US16570849
申请日：2019-09-13
IPC分类号： C07D401/14 , C07D417/12 , C07D401/12 , A61P27/06 , C07D413/12 , C07D405/12 , C07D417/14
摘要： Provided herein are amino isoquinolinyl amide and sulfonamide compounds that affect the function of kinases and other proteins in a cell and that are useful as therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and retinal diseases, as anti-inflammatory agents, for the treatment of cardiovascular diseases, and for diseases characterized by abnormal growth, such as cancers.
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公开(公告)号：US20180327381A1
公开(公告)日：2018-11-15
申请号：US15941993
申请日：2018-03-30
IPC分类号： C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D409/12 , C07D401/14 , A61P27/06
CPC分类号： C07D401/12 , A61P27/06 , C07C1/00 , C07C69/76 , C07C2601/02 , C07D217/02 , C07D217/22 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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公开(公告)号：US20230227430A1
公开(公告)日：2023-07-20
申请号：US17895436
申请日：2022-08-25
IPC分类号： C07D401/14 , A61P27/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D405/12 , C07D401/12
CPC分类号： C07D401/14 , A61P27/06 , C07D413/12 , C07D417/12 , C07D417/14 , C07D405/12 , C07D401/12
摘要： Provided herein are amino isoquinolinyl amide and sulfonamide compounds that affect the function of kinases and other proteins in a cell and that are useful as therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and retinal diseases, as anti-inflammatory agents, for the treatment of cardiovascular diseases, and for diseases characterized by abnormal growth, such as cancers.
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公开(公告)号：US11312700B2
公开(公告)日：2022-04-26
申请号：US16936257
申请日：2020-07-22
IPC分类号： C07D401/02 , C07D401/12 , C07D217/02 , C07D405/12 , C07D417/12 , C07D217/24 , C07D217/22 , C07D401/04 , C07D405/14 , C07C69/76 , A61P27/06 , C07D401/14 , C07D409/12
摘要： Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.
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