公开(公告)号：US10053490B2

公开(公告)日：2018-08-21

申请号：US15104186

申请日：2015-01-22

Applicant: Agency for Science, Technology and Research

Inventor： Brian Cheng San Chia

IPC: C07K5/087 ,  C07K5/117 ,  C07K1/00 ,  C07K1/06 ,  C07K1/10 ,  C07K5/02 ,  C07K5/065 ,  C07K5/072 ,  A61K38/00

CPC classification number: C07K5/0812 ,  A61K38/00 ,  C07K1/00 ,  C07K1/061 ,  C07K1/10 ,  C07K5/0212 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/1024

Abstract: The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.

公开(公告)号：US20200157144A1

公开(公告)日：2020-05-21

申请号：US16635401

申请日：2018-07-02

Applicant: Agency for Science, Technology and Research

Inventor： Brian Cheng San Chia

IPC: C07K5/08 ,  C07K5/10 ,  C07K5/06 ,  C07K7/06 ,  A61K9/00 ,  A61P31/04

Abstract: The present invention relates to peptides containing guanidine and halogenated biphenyl moieties of the formula (I), and to salts and solvates of each of these peptides and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.

公开(公告)号：US10787483B2

公开(公告)日：2020-09-29

申请号：US16038603

申请日：2018-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Brian Cheng San Chia

IPC: A61K38/06 ,  C07K5/087 ,  C07K5/117 ,  C07K1/00 ,  C07K1/06 ,  C07K1/10 ,  C07K5/02 ,  C07K5/065 ,  C07K5/072 ,  A61K38/00

Abstract: The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.

公开(公告)号：US20180354989A1

公开(公告)日：2018-12-13

申请号：US16038603

申请日：2018-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Brian Cheng San Chia

IPC: C07K5/087 ,  C07K5/117 ,  C07K5/072 ,  C07K5/065 ,  C07K5/02 ,  C07K1/10 ,  C07K1/06 ,  C07K1/00 ,  A61K38/00

Abstract: The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.