公开(公告)号：US20240238433A1

公开(公告)日：2024-07-18

申请号：US18562788

申请日：2022-05-20

Applicant: Agency for Science, Technology and Research

Inventor： Boon Hwa Andre CHOO ,  Ting Hwee GOH ,  Mei Yee DING ,  Hau Wan LEUNG ,  Simone DORFMUELLER ,  Ban Xiong TAN ,  Chek Shik LIM ,  Walter STUNKEL

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  G01N33/574 ,  G01N33/58

CPC classification number: A61K47/68031 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/2803 ,  G01N33/57492 ,  G01N33/58 ,  C07K2317/565 ,  C07K2317/567

Abstract: The invention relates to anti-CEACAM5/6 antigen-binding molecules and humanized variants thereof that bind to CEACAM5/6 that is glycosylated at N256. It also relates to the use of said antigen-binding molecules in methods of detection and medical treatment thereof.